Document Detail


Molecular aspects of epithelial γδ T cell regulation.
MedLine Citation:
PMID:  21481636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
γδ T cells lie at the interface between innate and adaptive immunity, sharing features with both arms of the immune system. The vast majority of γδ T cells reside in epithelial layers of tissues such as skin, gut, lung, tongue and reproductive tract where they provide a first line of defense against environmental attack. The existence of epithelium-resident γδ T cells has been known for over 20 years but our understanding of the molecular events regulating development and function of these cells is incomplete. We review recent advances in the field, with particular emphasis on the γδ T cell population resident in mouse epidermis. These studies have enhanced our knowledge and understanding of the life cycle of this enigmatic population of cells.
Authors:
Deborah A Witherden; Wendy L Havran
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-04-12
Journal Detail:
Title:  Trends in immunology     Volume:  32     ISSN:  1471-4981     ISO Abbreviation:  Trends Immunol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-06     Completed Date:  2011-08-22     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Lineage
Epithelial Cells / immunology*
Humans
Receptors, Antigen, T-Cell, gamma-delta / immunology*
T-Lymphocytes / cytology,  immunology*
Grant Support
ID/Acronym/Agency:
AI036964/AI/NIAID NIH HHS; AI64811/AI/NIAID NIH HHS; GM080301/GM/NIGMS NIH HHS; R01 AI036964/AI/NIAID NIH HHS; R01 AI036964-13/AI/NIAID NIH HHS; R01 AI064811/AI/NIAID NIH HHS; R01 AI064811-05/AI/NIAID NIH HHS; R01 GM080301/GM/NIGMS NIH HHS; R01 GM080301-04/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Antigen, T-Cell, gamma-delta
Comments/Corrections

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