| Molecular architecture of the sperm flagella: molecules for motility and signaling. | |
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MedLine Citation:
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PMID: 14578564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sperm motility is generated by a highly organized, microtubule-based structure, called the axoneme, which is constructed from approximately 250 proteins. Recent studies have revealed the molecular structures and functions of a number of axonemal components, including the motor molecules, the dyneins, and regulatory substructures, such as radial spoke, central pair, and other accessory structures. The force for flagellar movement is exerted by the sliding of outer-doublet microtubules driven by the molecular motors, the dyneins. Dynein activity is regulated by the radial spoke/central pair apparatus through protein phosphorylation, resulting in flagellar bend propagation. Prior to fertilization, sperm exhibit dramatic motility changes, such as initiation and activation of motility and chemotaxis toward the egg. These changes are triggered by changes in the extracellular ionic environment and substances released from the female reproductive tract or egg. After reception of these extracellular signals by specific ion channels or receptors in the sperm cells, intracellular signals are switched on through tyrosine protein phosphorylation, Ca2+, and cyclic nucleotide-dependent pathways. All these signaling molecules are closely arranged in each sperm flagellum, leading to efficient activation of motility. |
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Authors:
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Kazuo Inaba |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Zoological science Volume: 20 ISSN: 0289-0003 ISO Abbreviation: Zool. Sci. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-10-27 Completed Date: 2004-01-05 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8702287 Medline TA: Zoolog Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1043-56 Citation Subset: IM |
Affiliation:
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Asamushi Marine Biological Station, Graduate School of Science, Tohoku University, Aomori, Japan. inaba@biology.tohoku.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology Cations / metabolism Dyneins / genetics* Flagella / genetics* Ion Channels / metabolism Male Signal Transduction* Sperm Motility / genetics, physiology* Spermatozoa / cytology* |
| Chemical | |
Reg. No./Substance:
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0/Cations; 0/Ion Channels; EC 3.6.4.2/Dyneins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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