Document Detail

Molecular architecture of the mammalian circadian clock.
MedLine Citation:
PMID:  23916625     Owner:  NLM     Status:  Publisher    
Circadian clocks coordinate physiology and behavior with the 24h solar day to provide temporal homeostasis with the external environment. The molecular clocks that drive these intrinsic rhythmic changes are based on interlocked transcription/translation feedback loops that integrate with diverse environmental and metabolic stimuli to generate internal 24h timing. In this review we highlight recent advances in our understanding of the core molecular clock and how it utilizes diverse transcriptional and post-transcriptional mechanisms to impart temporal control onto mammalian physiology. Understanding the way in which biological rhythms are generated throughout the body may provide avenues for temporally directed therapeutics to improve health and prevent disease.
Carrie L Partch; Carla B Green; Joseph S Takahashi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-31
Journal Detail:
Title:  Trends in cell biology     Volume:  -     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-8-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA; Center for Chronobiology, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:
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