Document Detail


Molecular applications for identifying microbial pathogens in the post-9/11 era.
MedLine Citation:
PMID:  15934819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rapid advances in molecular and optical technologies over the past 10 years have dramatically impacted the way biologic research is conducted today. Examples include microarrays, capillary sequencing, optical mapping and real-time sequencing (Pyrosequencing). These technologies are capable of rapidly delivering massive amounts of genetic information and are becoming routine mainstays of many laboratories. Fortunately, advances in scientific computing have provided the enormous computing power necessary to analyze these enormous data sets. The application of molecular technologies should prove useful to the burgeoning field of microbial forensics. In the post-9/11 era, when securing America's food supply is a major endeavor, the need for rapid identification of microbes that accidentally or intentionally find their way into foods is apparent. The principle that distinguishes a microbial forensic investigation from a molecular epidemiology study is that a biocrime has been committed. If proper attribution is to be attained, a link must be made between a particular microbe in the food and the perpetrator who placed it there. Therefore, the techniques used must be able to discriminate individual isolates of a particular microbe. A battery of techniques in development for distinguishing individual isolates of particular foodborne pathogens is discussed.
Authors:
Thomas A Cebula; Eric W Brown; Scott A Jackson; Mark K Mammel; Amit Mukherjee; J Eugene LeClerc
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Expert review of molecular diagnostics     Volume:  5     ISSN:  1744-8352     ISO Abbreviation:  Expert Rev. Mol. Diagn.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2007-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120777     Medline TA:  Expert Rev Mol Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-45     Citation Subset:  IM    
Affiliation:
Center for Food Safety & Applied Nutrition, Office of Applied Research & Safety Assessment (HFS-025), US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. Thomas.Cebula@fda.hhs.gov
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MeSH Terms
Descriptor/Qualifier:
Bioterrorism*
Computational Biology
Food Microbiology*
Humans
Microbiological Techniques / methods*,  trends
Phylogeny
September 11 Terrorist Attacks*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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