| Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. | |
| | |
MedLine Citation:
|
PMID: 18585065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Regulatory T (Treg) and T helper 17 (Th17) cells were recently proposed to be reciprocally regulated during differentiation. To understand the underlying mechanisms, we utilized a Th17 reporter mouse with a red fluorescent protein (RFP) sequence inserted into the interleukin-17F (IL-17F) gene. Using IL-17F-RFP together with a Foxp3 reporter, we found that the development of Th17 and Foxp3(+) Treg cells was associated in immune responses. Although TGF-beta receptor I signaling was required for both Foxp3 and IL-17 induction, SMAD4 was only involved in Foxp3 upregulation. Foxp3 inhibited Th17 differentiation by antagonizing the function of the transcription factors RORgammat and ROR*. In contrast, IL-6 overcame this suppressive effect of Foxp3 and, together with IL-1, induced genetic reprogramming in Foxp3(+) Treg cells. STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells. Our data demonstrate molecular antagonism and plasticity of Treg and Th17 cell programs. |
| | |
Authors:
|
Xuexian O Yang; Roza Nurieva; Gustavo J Martinez; Hong Soon Kang; Yeonseok Chung; Bhanu P Pappu; Bhavin Shah; Seon Hee Chang; Kimberly S Schluns; Stephanie S Watowich; Xin-Hua Feng; Anton M Jetten; Chen Dong |
Related Documents
:
|
20134195 - Disease-modifying immunotherapy for the management of autoimmune diabetes. 1515555 - Production and induction of a novel cytotoxin (factor 2) by a human b-cell line. 19272445 - Methyl beta-cyclodextrin reduces accumulation of reactive oxygen species and cell death... 2504565 - Quantitative immunofluorescence in single saccharomyces cerevisiae cells. 18295335 - Modulation of murine complement receptor type 2 (cr2/cd21) ectodomain shedding by its c... 17240335 - Cryptic quantitative evolution of the vulva intercellular signaling network in caenorha... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2008-06-26 |
Journal Detail:
|
Title: Immunity Volume: 29 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-07-17 Completed Date: 2008-08-12 Revised Date: 2011-08-01 |
Medline Journal Info:
|
Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
|
Languages: eng Pagination: 44-56 Citation Subset: IM |
Affiliation:
|
Department of Immunology, M.D. Anderson Cancer Center, Houston, TX 77030, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Differentiation / immunology* Encephalomyelitis, Autoimmune, Experimental / immunology Female Flow Cytometry Immunoprecipitation Inflammation / immunology* Interleukin-17 / immunology, metabolism Lymphocyte Activation / immunology Mice Mice, Transgenic Polymerase Chain Reaction Signal Transduction / immunology T-Lymphocyte Subsets / cytology*, immunology T-Lymphocytes, Helper-Inducer / cytology*, immunology T-Lymphocytes, Regulatory / cytology*, immunology Transduction, Genetic Transforming Growth Factor beta1 / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
AR050772/AR/NIAMS NIH HHS; CA108454/CA/NCI NIH HHS; R01 AI050746-01/AI/NIAID NIH HHS; Z01 ES101586-05/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-17; 0/Transforming Growth Factor beta1 |
| Comments/Corrections | |
Comment In:
|
Immunotherapy. 2009 Jan;1(1):27-9
[PMID:
20635970
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17...
Next Document: Ustilago maydis secondary metabolism-from genomics to biochemistry.