Document Detail

Molecular analysis of thrombophilic risk factors in patients with dural arteriovenous fistulas.
MedLine Citation:
PMID:  12111299     Owner:  NLM     Status:  MEDLINE    
Dural arteriovenous fistulas (DAVFs) are direct artery-to-cerebral venous sinus shunts. Our recent finding of a significantly increased prevalence of factor V (FV) Leiden in patients with DAVFs prompted us to evaluate prothrombinG20210A, MTHFRC677T, beta-fibrinogenG455A, PAI-14G/5G and FXIIIVal34Leu as additional risk factors for thrombophilia in 26 patients with DAVFs and a group of age- and gender-matched controls. There was no significantly increased prevalence of these risk factors in DAVF patients. We conclude that FV Leiden is of pathogenetic significance in the aetiology of a subgroup of DAVFs whereas the other thrombophilic risk factors are not likely to be involved.
Jürgen A Kraus; Bettina K Stüper; Jens Müller; Hans-C Nahser; Thomas Klockgether; Peter Berlit; Ursula Harbrecht
Related Documents :
24395709 - Double effort: parental behavior of wild azara's owl monkeys in the face of twins.
2755549 - Cerebral palsy in tottori, japan. benefits and risks of progress in perinatal medicine.
6660419 - Low cerebral perfusion pressure: an indicator of poor prognosis in asphyxiated term inf...
7784819 - Cranial nerve palsies and cerebral infarction in a young infant with meningococcal meni...
15113629 - Association of cord blood cytokines with prematurity and cerebral palsy.
18787659 - Cerebral ventricular volume and temperamental difficulties in infancy. the generation r...
23618409 - Intra-partum fever and cerebral palsy in khartoum, sudan.
11004639 - Constipation presenting as recurrent vulvovaginitis in prepubertal children.
23458419 - Coordinated release of tissue factor and tissue factor pathway inhibitor in vlbw infants.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  249     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-11     Completed Date:  2002-09-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  680-2     Citation Subset:  IM    
Department of Neurology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Case-Control Studies
Central Nervous System Vascular Malformations / blood*,  genetics*,  physiopathology
Cranial Sinuses / pathology,  physiopathology*
Factor V / genetics,  metabolism
Factor XIII / genetics,  metabolism
Fibrinogen / genetics,  metabolism
Gene Frequency
Genetic Predisposition to Disease / genetics
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation / genetics
Oxidoreductases Acting on CH-NH Group Donors / genetics,  metabolism
Plasminogen Activator Inhibitor 1 / genetics,  metabolism
Polymorphism, Genetic / genetics
Protein C / genetics,  metabolism
Prothrombin / genetics,  metabolism
Risk Factors
Thrombophilia / blood,  complications*,  genetics*
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; 0/Protein C; 0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; 9001-32-5/Fibrinogen; 9013-56-3/Factor XIII; EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Changes in cerebral glycolytic activity during transport of critically ill neurotrauma patients meas...
Next Document:  What is pathological with gaze shift fragmentation in Parkinson's disease?