Document Detail


Molecular analysis of thrombophilic risk factors in patients with dural arteriovenous fistulas.
MedLine Citation:
PMID:  12111299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dural arteriovenous fistulas (DAVFs) are direct artery-to-cerebral venous sinus shunts. Our recent finding of a significantly increased prevalence of factor V (FV) Leiden in patients with DAVFs prompted us to evaluate prothrombinG20210A, MTHFRC677T, beta-fibrinogenG455A, PAI-14G/5G and FXIIIVal34Leu as additional risk factors for thrombophilia in 26 patients with DAVFs and a group of age- and gender-matched controls. There was no significantly increased prevalence of these risk factors in DAVF patients. We conclude that FV Leiden is of pathogenetic significance in the aetiology of a subgroup of DAVFs whereas the other thrombophilic risk factors are not likely to be involved.
Authors:
Jürgen A Kraus; Bettina K Stüper; Jens Müller; Hans-C Nahser; Thomas Klockgether; Peter Berlit; Ursula Harbrecht
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  249     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-11     Completed Date:  2002-09-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  680-2     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Central Nervous System Vascular Malformations / blood*,  genetics*,  physiopathology
Cranial Sinuses / pathology,  physiopathology*
Factor V / genetics,  metabolism
Factor XIII / genetics,  metabolism
Female
Fibrinogen / genetics,  metabolism
Gene Frequency
Genetic Predisposition to Disease / genetics
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation / genetics
Oxidoreductases Acting on CH-NH Group Donors / genetics,  metabolism
Plasminogen Activator Inhibitor 1 / genetics,  metabolism
Polymorphism, Genetic / genetics
Protein C / genetics,  metabolism
Prothrombin / genetics,  metabolism
Risk Factors
Thrombophilia / blood,  complications*,  genetics*
Chemical
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; 0/Protein C; 0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; 9001-32-5/Fibrinogen; 9013-56-3/Factor XIII; EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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