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Molecular analysis of lymphoid malignancies.
MedLine Citation:
PMID:  21594379     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Although lymphoid malignancies have been widely studied at the molecular level, no group has reported on the simultaneous investigation of t(14;18) chromosomal translocation, B-cell clonality and bcl2 gene expression. We have performed PCR analysis of t(14;18) translocation and B-cell clonality as well as semi-quantitation of bcl2 expression by Western blotting on a group of 41 patients treated at our institution for lymphoid malignancies. The t(14;18) translocation was observed in 10 out of 40 cases (25%) with a prevalence in the subgroup of centrofollicular lymphoma (9 out of 19, or 47%, which includes one patient in complete clinical remission). bcl2 was overexpressed in 84% of the patients (21/25) and B monoclonality was observed in 21 out of 37 B-cell neoplasia patients (57%) with or without a t(14;18) translocation. In 4 patients, bcl2 overexpression, which has been implicated in the sensitivity to a variety of cytotoxic drugs, was the only abnormality detected. Studies are currently underway to determine whether semi-quantitation of bcl2 expression provides improved prediction of a patient's response to chemotherapy.
Authors:
N Frenoy; M Gildelgado; P Pham; M Salvucci; A Chahine; A Chabli; J Misset; B Debuire
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  3     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  2011-05-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  385-90     Citation Subset:  -    
Affiliation:
HOP PAUL BROUSSE,SERV BIOCHIM,F-94804 VILLEJUIF,FRANCE. HOP PAUL BROUSSE,SERV MALAD SANGUINES IMMUNITAIRES & TUMORALES,F-94804 VILLEJUIF,FRANCE.
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