Document Detail

Molecular analysis of lymphoid malignancies.
MedLine Citation:
PMID:  21594379     Owner:  NLM     Status:  In-Data-Review    
Although lymphoid malignancies have been widely studied at the molecular level, no group has reported on the simultaneous investigation of t(14;18) chromosomal translocation, B-cell clonality and bcl2 gene expression. We have performed PCR analysis of t(14;18) translocation and B-cell clonality as well as semi-quantitation of bcl2 expression by Western blotting on a group of 41 patients treated at our institution for lymphoid malignancies. The t(14;18) translocation was observed in 10 out of 40 cases (25%) with a prevalence in the subgroup of centrofollicular lymphoma (9 out of 19, or 47%, which includes one patient in complete clinical remission). bcl2 was overexpressed in 84% of the patients (21/25) and B monoclonality was observed in 21 out of 37 B-cell neoplasia patients (57%) with or without a t(14;18) translocation. In 4 patients, bcl2 overexpression, which has been implicated in the sensitivity to a variety of cytotoxic drugs, was the only abnormality detected. Studies are currently underway to determine whether semi-quantitation of bcl2 expression provides improved prediction of a patient's response to chemotherapy.
N Frenoy; M Gildelgado; P Pham; M Salvucci; A Chahine; A Chabli; J Misset; B Debuire
Related Documents :
17052809 - Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces ...
25429209 - Soluble receptor for advanced glycation end products in critically ill patients and its...
8598429 - Enteral nutritional support in acute alcoholic pancreatitis.
20975519 - Effects of body weight on tolerability of rivastigmine transdermal patch: a post-hoc an...
21722709 - Pre-screening and follow-up of childhood acute leukemia using biochemical infrared anal...
22781909 - Histological loss of pancreatic exocrine cells correlates with pancreatic exocrine func...
17071039 - Contrast enhanced sonography of the gallbladder: a tool in the diagnosis of cholecystitis?
8253549 - Multiple nodules of intermediate trophoblast following hydatidiform moles.
20630689 - Clinical course of asymptomatic patients with carotid duplex scan end diastolic velocit...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  3     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  2011-05-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  385-90     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endoglin (CD105) expression in non-neoplastic and neoplastic human tissues and human cancer cell lin...
Next Document:  A phase I evaluation of chronotropic delivery of floxuridine by hepatic arterial infusion in patient...