| Molecular analysis of increased iron status in moderately exercised rats. | |
| | |
MedLine Citation:
|
PMID: 16317519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although iron plays a critical role in exercise, the regulatory mechanism of iron metabolism remains poorly understood. The aims of the present study were to investigate the effects of different intensity exercise on body iron status and the regulatory mechanism of duodenal iron absorption. Thirty female Sprague-Dawley rats (90-100 g) were randomly divided into three groups: a control group (remained sedentary, CG), a moderately exercised group (swam 1.5 h/day, MG) and a strenuously exercised group (swam with different load, SG). Serum iron status, serum ferritin and Hct were examined after 10 weeks of swimming. Western blot was performed to detect the expression of iron transport proteins: divalent metal transporter1 (DMT1) and ferroportin 1 (FPN1) in duodenal epithelium. The expression of hepcidin mRNA in liver was examined by RT-PCR. The results showed: (1) the body iron status in MG was kept at a high level compared to that of CG and SG, (2) Western blot showed DMT1 with iron responsive element (IRE) and FPN1 in duodenal epithelium which were higher in MG than that of CG and (3) the expression of hepatic hepcidin mRNA was down regulated in MG (p < 0.05). The data suggested that moderate exercise improved iron status and that was likely regulated by increased DMT1 with IRE and FPN1 expression. Hepcidin signaling pathway may involve in the regulation of duodenal iron absorption proteins. |
| | |
Authors:
|
Yu Qian Liu; Xiang Lin Duan; Yan Zhong Chang; Hai Tao Wang; Zhong Ming Qian |
Related Documents
:
|
7173139 - Changes in blood neutrophil/lymphocyte ratio related to adrenocortical function in the ... 11985939 - Branched-chain amino acid supplementation and the immune response of long-distance athl... 8164529 - Exercise, upper respiratory tract infection, and the immune system. 9810649 - Respiratory burst of human polymorphonuclear leukocytes in response to the galactoside-... 2127819 - Human neutrophil hydrogen peroxide generation following physical exercise. 17919919 - Serum from exercising humans suppresses t-cell cytokine production. 10732079 - Equine retained placenta: technique for and tolerance to umbilical artery injections of... 8976309 - Lower extremity blood flow and responses to occlusion ischemia differ in exercise-train... 18343519 - Neuroprotective effects of t-817ma against noise-induced hearing loss. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Molecular and cellular biochemistry Volume: 282 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-11-30 Completed Date: 2006-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 117-23 Citation Subset: IM |
Affiliation:
|
The Laboratory of Animal Cytobiology, College of Life Science, Hebei Normal University, Hebei Province, Shijiazhuang 050016, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antimicrobial Cationic Peptides / metabolism Cation Transport Proteins / metabolism Duodenum / metabolism Female Ferritins / blood Hemoglobins / metabolism Intestinal Mucosa / metabolism Iron / metabolism* Liver / metabolism Physical Conditioning, Animal* Random Allocation Rats Rats, Sprague-Dawley Response Elements Swimming |
| Chemical | |
Reg. No./Substance:
|
0/Antimicrobial Cationic Peptides; 0/Cation Transport Proteins; 0/Hemoglobins; 0/hepcidin; 0/metal transporting protein 1; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A low degree of fatty acid unsaturation leads to high resistance to lipid peroxidation in mitochondr...
Next Document: Inhibition of nitric oxide and caspase-3 mediated apoptosis by a tetrapeptide derivative (PEP1261) i...