Document Detail


Molecular analysis of hepatitis B virus in Bulgaria.
MedLine Citation:
PMID:  23154875     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hepatitis B virus infection is a global health problem. Based on the sequence divergence of the entire genome, hepatitis B virus has been classified into eight genotypes which have a characteristic geographic distribution. To date, no data are available on the molecular epidemiology of hepatitis B virus in Bulgaria. The aim of the present study was to reconstruct the epidemiological history of HBV genotypes/subgenotypes circulating in Bulgaria using a phylodynamic approach and a Bayesian statistical inference framework. Sequence analysis of the HBsAg/Reverse Transcriptase overlapping genomic regions revealed that D1 and A2 were the subgenotypes detected most frequently in the patients examined. The tMRCA estimations of the few HBV D1 Bulgarian significant clades dated back to 23-27 years ago, corresponding to the early 1980s. The HBV A2 Bulgarian sequences fell into two closely related supported clusters dated to 2003 and 1996 years, respectively, suggesting a more recent introduction of subgenotype A2 into Bulgaria. The study provides new information about the HBV subgenotypes in Bulgaria. J. Med. Virol. 85:49-54, 2012. © 2012 Wiley Periodicals, Inc.
Authors:
Massimo Ciccozzi; Muhammed Babakir-Mina; Alessandra Lo Presti; Romina Salpini; Eleonora Cella; Elena Gabanelli; Pavel Teoharov; Ani Kevorkyan; Carlo Federico Perno; Gianguglielmo Zehender; Marco Ciotti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  85     ISSN:  1096-9071     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Infectious, Parasitic, and Immunomediated Disease, National Institute of Health, Rome, Italy.
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