| Molecular analysis of hepatitis B virus associated with vaccine failure in infants and mothers: A case-control study in Thailand. | |
| | |
MedLine Citation:
|
PMID: 22711345 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Perinatal transmission of hepatitis B virus (HBV) has been controlled incompletely despite adequate immunoprophylaxis in infants. The aim of this study was to characterize virological factors of HBV associated with vaccine failure in Thailand. Sera of 14 infected infants (13 HBeAg-positive and one HBeAg-negative) with vaccine failure and their respective mothers (group M1) were tested quantitatively for HBV DNA by real-time PCR, HBV genotypes and mutations were characterized by direct sequencing. Sera collected from 15 HBeAg-positive (group M2) and 15 HBeAg-negative (group M3) mothers whose infants had been vaccinated successfully served as controls. The results showed that group M1 and group M2 mothers had equal titers of HBV DNA but higher titers than group M3. All infected infants and their respective mothers had the same HBeAg status and HBV genotypes. DNA analysis in a pair of HBeAg-negative infant and mother revealed that both were infected with an HBV precore mutant (G1896A). Escape mutants in the "a" determinant region (residues 144 and 145) were detected in two (14%) infected infants. The prevalence of BCP mutations/deletions in groups M2 and M3 was higher significantly than in group M1 (P = 0.022 and P < 0.001, respectively). In conclusion, instead of the HBeAg status, a high titer of HBV DNA in mothers was the major contributor to perinatal transmission of HBV. Escape mutants might be associated with vaccine failure in some infants. BCP mutations/deletions in mothers might contribute to the prevention of mother-to-infant transmission of HBV. J. Med. Virol. 84: 1177-1185, 2012. © 2012 Wiley Periodicals, Inc. |
| | |
Authors:
|
Pattaratida Sa-Nguanmoo; Pisit Tangkijvanich; Piyanit Tharmaphornpilas; Aim-Orn Rasdjarmrearnsook; Saowanee Plianpanich; Nutchanart Thawornsuk; Apiradee Theamboonlers; Yong Poovorawan |
Related Documents
:
|
22538325 - The effect of massage on heart rate variability in preterm infants. 23216355 - A multi-parameter system for use in neonatal resuscitation research and training. 16504905 - Satisfaction with planned place of birth among midwifery clients in british columbia. 9029705 - Trends and characteristics of births attended by midwives. 14571225 - Early feeding after necrotizing enterocolitis in preterm infants. 21952535 - Early postnatal surge of serum clara cell secretory protein in newborn infants. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of medical virology Volume: 84 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-06-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
|
Languages: eng Pagination: 1177-85 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vitro replication phenotype of a novel (-1G) hepatitis B virus variant associated with HIV co-inf...
Next Document: Prevalence, risk factors, and molecular epidemiology of hepatitis B and hepatitis delta virus in pre...