Document Detail

Molecular analysis of a developmentally regulated gene which is expressed in the larval salivary gland of Drosophila.
MedLine Citation:
PMID:  6200375     Owner:  NLM     Status:  MEDLINE    
The polytene genome of the larval salivary gland of Drosophila undergoes dramatic alterations in localized transcriptional activity late in third-instar development. One of these changes involves the 20-OH ecdysone-mediated and coordinate repression of a dispersed set of intermolt puff sites. The DNA from one of these loci (that located within the 90BC interval) has been isolated by molecular cloning techniques. This DNA was shown to be present one time per haploid Drosophila genome and to contain a gene (designated the Group V gene) which is developmentally regulated. The Group V transcript was shown to accumulate only during third-instar larval development and to be located exclusively in the salivary gland. These results are consistent with the hypothesis that the Group V gene codes for a salivary gland glue protein.
G M Guild
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  102     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-18     Completed Date:  1984-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  462-70     Citation Subset:  IM    
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MeSH Terms
DNA / metabolism*
DNA Restriction Enzymes
DNA, Recombinant
Drosophila melanogaster / genetics*,  growth & development
Ecdysterone / genetics
Gene Expression Regulation
Larva / genetics
Nucleic Acid Hybridization
RNA / genetics
Salivary Glands / analysis
Transcription, Genetic
Reg. No./Substance:
0/DNA, Recombinant; 5289-74-7/Ecdysterone; 63231-63-0/RNA; 9007-49-2/DNA; EC 3.1.21.-/DNA Restriction Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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