Document Detail


Molecular analysis of HIV type 1 vif sequences from Cape Town, South Africa.
MedLine Citation:
PMID:  18593349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
South Africa has the highest number of HIV-1-infected individuals in the world, with HIV-1 subtype C prevailing. However, HIV-1 subtype C accessory genes are rarely characterized in the country. These genes are important for establishing viral pathogenesis. The Vif protein has been shown to counteract the antiretroviral activity of APOBEC3G/F cytidine deaminases. In this study an additional 50 HIV-1 vif sequences are characterized. These include 48 HIV-1 subtype C and 2 HIV-1 subtype B sequences. Highly conserved HIV-1 subtype C motifs are outlined. The previously identified RLRR (90-93) motif does not seem to be conserved among our newly analyzed sequences. Conserved motifs can be useful for developing new vaccine strategies or antiretroviral drugs.
Authors:
Graeme B Jacobs; Markus Nistal; Annette Laten; Estrelita Janse van Rensburg; Axel Rethwilm; Wolfgang Preiser; Jochen Bodem; Susan Engelbrecht
Related Documents :
7797929 - Extent and kinetics of genetic change in the omp1 gene of chlamydia trachomatis in two ...
19956739 - An evolutionary model-based algorithm for accurate phylogenetic breakpoint mapping and ...
9618079 - Genetic characterization of hiv type 1 from migrant workers in three south african gold...
16428889 - Ugandan kaposi's sarcoma-associated herpesvirus phylogeny: evidence for cross-ethnic tr...
8808329 - Functionality of chimeric rev proteins of hiv/siv.
15929699 - The x4 phenotype of hiv type 1 evolves from r5 in two children of mothers, carrying x4,...
7816029 - Toxicity of a heterologous leucyl-trna (anticodon cag) in the pathogen candida albicans...
16815149 - Analysis of gene expression profiles of normal human nasal mucosa and nasal polyp tissu...
12049169 - Ubiquitin genes in rainbow trout (oncorhynchus mykiss).
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  24     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  991-4     Citation Subset:  IM; X    
Affiliation:
Division of Medical Virology, National Health Laboratory Service (NHLS) and University of Stellenbosch, Tygerberg 7505, Cape Town, South Africa.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/EU269071;  EU269072;  EU269073;  EU269074;  EU269075;  EU269076;  EU269077;  EU269078;  EU269079;  EU269080;  EU269081;  EU269082;  EU269083;  EU269084;  EU269085;  EU269086;  EU269087;  EU269088;  EU269089;  EU269090;  EU269091;  EU269092;  EU269093;  EU269094;  EU269095;  EU269096;  EU269097;  EU269098;  EU269099;  EU269100;  EU269101;  EU269102;  EU269103;  EU269104;  EU269105;  EU269106;  EU269107;  EU269108;  EU269109;  EU269110;  EU269111;  EU269112;  EU269113;  EU269114;  EU269115;  EU269116;  EU269117;  EU269118;  EU269119;  EU269120;  EU269121;  EU269122;  EU269123;  EU269124;  EU269125;  EU269126;  EU269127;  EU269128;  EU269129;  EU269130;  EU269131;  EU269132;  EU269133;  EU269134;  EU269135;  EU269136;  EU269137;  EU269138;  EU269139;  EU269140;  EU269141;  EU269142;  EU269143;  EU269144;  EU269145;  EU269146;  EU269147;  EU269148;  EU269149;  EU269150;  EU269151;  EU269152;  EU269153;  EU269154;  EU269155;  EU269156;  EU269157;  EU269158;  EU269159;  EU269160;  EU269161;  EU269162;  EU269163;  EU269164;  EU269165;  EU269166;  EU269167;  EU269168;  EU269169;  EU269170;  EU269171;  EU269172;  EU269173;  EU269174;  EU269175;  EU269176;  EU269177;  EU269178;  EU269179;  EU269180;  EU269181;  EU269182;  EU269183;  EU269184;  EU269185;  EU269186;  EU269187;  EU269188;  EU269189;  EU269190;  EU269191;  EU269192;  EU269193;  EU269194;  EU269195;  EU269196;  EU269197;  EU269198;  EU269199;  EU269200;  EU269201;  EU269202;  EU269203;  EU269204;  EU269205;  EU269206;  EU269207;  EU269208;  EU269209;  EU269210;  EU269211;  EU269212;  EU269213;  EU269214;  EU269215;  EU269216;  EU269217;  EU269218;  EU269219;  EU269220;  EU269221;  EU269222;  EU269223;  EU269224;  EU269225;  EU269226;  EU269227;  EU269228;  EU269229;  EU269230;  EU269231;  EU269232;  EU269233;  EU269234;  EU269235;  EU269236;  EU269237;  EU269238;  EU269239;  EU269240;  EU269241;  EU269242;  EU269243;  EU269244;  EU269245;  EU269246;  EU269247;  EU269248;  EU269249;  EU269250;  EU269251;  EU269252;  EU269253;  EU269254;  EU269255;  EU269256;  EU269257;  EU269258;  EU269259;  EU269260;  EU269261;  EU269262;  EU269263;  EU269264;  EU269265;  EU269266;  EU269267;  EU269268;  EU269269;  EU269270;  EU269271;  EU269272;  EU269273;  EU269274;  EU269275;  EU269276;  EU269277;  EU269278;  EU269279;  EU269280;  EU269281;  EU269282;  EU269283;  EU269284;  EU269285;  EU269286;  EU269287;  EU269288;  EU269289;  EU269290;  EU269291;  EU269292;  EU269293;  EU269294;  EU269295;  EU269296;  EU269297;  EU269298;  EU269299;  EU269300;  EU269301;  EU269302;  EU269303;  EU269304;  EU269305;  EU269306;  EU269307;  EU269308;  EU269309;  EU269310;  EU269311;  EU269312;  EU269313;  EU269314;  EU269315;  EU269316;  EU269317;  EU269318;  EU269319;  EU269320;  EU269321;  EU269322;  EU269323;  EU269324;  EU269325;  EU269326;  EU269327;  EU269328;  EU269329;  EU269330;  EU269331;  EU269332;  EU269333;  EU269334;  EU269335;  EU269336;  EU269337;  EU269338;  EU269339;  EU269340;  EU269341;  EU269342;  EU269343;  EU269344;  EU269345;  EU269346;  EU269347;  EU269348;  EU269349;  EU269350;  EU269351;  EU269352;  EU269353;  EU269354;  EU269355;  EU269356;  EU269357;  EU269358;  EU269359;  EU269360;  EU269361;  EU269362;  EU269363;  EU269364;  EU269365;  EU269366;  EU269367;  EU269368;  EU269369;  EU269370;  EU269371;  EU269372;  EU269373;  EU269374;  EU269375;  EU269376;  EU269377;  EU269378;  EU269379;  EU269380;  EU269381;  EU269382;  EU269383;  EU269384;  EU269385;  EU269386;  EU269387;  EU269388;  EU269389;  EU269390;  EU269391;  EU269392;  EU269393;  EU269394;  EU269395;  EU269396;  EU269397;  EU269398;  EU269399;  EU269400;  EU269401;  EU269402;  EU269403;  EU269404;  EU269405;  EU269406;  EU269407;  EU269408;  EU269409;  EU269410;  EU269411;  EU269412;  EU269413;  EU269414;  EU269415;  EU269416;  EU269417;  EU269418;  EU269419;  EU269420;  EU269421;  EU269422;  EU269423;  EU269424;  EU269425;  EU269426;  EU269427;  EU269428;  EU269429;  EU269430;  EU269431;  EU269432;  EU269433;  EU269434;  EU269435;  EU269436;  EU269437;  EU269438;  EU269439;  EU269440;  EU269441;  EU269442;  EU269443;  EU269444;  EU269445;  EU269446;  EU269447;  EU269448;  EU269449;  EU269450;  EU269451;  EU269452;  EU269453;  EU269454;  EU269455;  EU269456;  EU269457;  EU269458;  EU269459
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Motifs / genetics
Amino Acid Sequence
Female
Gene Products, vif / genetics*
HIV Infections / virology*
HIV-1 / genetics
Humans
Male
Molecular Sequence Data
Sequence Alignment
South Africa
Chemical
Reg. No./Substance:
0/Gene Products, vif

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Discrepancies in assignment of subtype/recombinant forms by genotyping programs for HIV type 1 drug ...
Next Document:  Phylogenetic diversity and low level antiretroviral resistance mutations in HIV type 1 treatment-nai...