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Molecular Understanding of the Compaction Behaviour of Indomethacin Polymorphs.
MedLine Citation:
PMID:  23301663     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polymorphs enable us to gain molecular insights into the compaction behaviour of pharmaceutical powders. Two polymorphs (α and γ) of indomethacin (IMC) were investigated for in-die and out-of-die compaction behavior using compressibility, tabletability and compactibility (CTC) profile, stress-strain relationship, Heckel, Kawakita and Walker equations. Compaction studies were performed on a fully instrumented rotary tabletting machine. CTC analysis revealed that γ-form has increased compressibility while α-form showed greater compactibility. The α-form also showed increased tabletibility over γ-form at all the compaction pressures. Lower values of Py (Heckel parameter) and 1/b (Kawakita parameter) indicated increased deformation behaviour of γ-form. Stress-strain analysis also supports the increased compressibility of γ-form. In addition, Walker analysis showed higher compressibility coefficient (W) for α-form, consistent with its greater tabletability. Thus, tabletability of IMC polymorphs was governed by the compactibility of the material. Detailed examination of crystallographic data revealed that presence of slip plane system in γ-form offered it increased compressibility and deformation behaviour. However, α-form showed greater compactibility by virtue of closer molecular packing (higher true density). Hence, although direct correlation between tabletability and presence of slip planes in the crystals has been reported, prediction solely based on this crystallographic feature must be avoided. Present work reiterates the influence of the crystal packing on the tabletability of the pharmaceutical polymorphs.
Authors:
Kailas S Khomane; Parth K More; Guru Raghavendra; Arvind K Bansal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Molecular pharmaceutics     Volume:  -     ISSN:  1543-8392     ISO Abbreviation:  Mol. Pharm.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197791     Medline TA:  Mol Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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