Document Detail


Molecular Pathways: PI3-kinase pathway targets in triple negative breast cancers.
MedLine Citation:
PMID:  23748695     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The triple negative breast cancer (TNBC) subtype defined clinically by the lack of estrogen, progesterone, and Her2 receptor expression, accounts for 10 to 15% of annual breast cancer diagnoses. Currently, limited therapeutic options have shown clinical benefit beyond cytotoxic chemotherapy. Defining this clinical cohort and identifying subtype specific molecular targets remains critical for new therapeutic development. The current era of high-throughput molecular analysis have revealed new insights into these targets and have confirmed the PI3-kinase as a key player in pathogenesis. The improved knowledge of the molecular basis of TNBC in parallel with efforts to develop new PI3-kinase pathway-specific inhibitors may finally produce the therapeutic breakthrough that is desperately needed.
Authors:
Vallerie Gordon; Shantanu Banerji
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-7
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  -     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Medical Oncology and Haematology, CancerCare Manitoba.
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