Document Detail

Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review.
MedLine Citation:
PMID:  22389749     Owner:  NLM     Status:  Publisher    
The renin-angiotensin system is an essential regulatory system for blood pressure and fluid homeostasis. Angiotensinogen is the only known precursor of all the peptides generated in this system. While many of the basic understandings of angiotensinogen have come from research efforts to define its role in blood pressure regulation, novel pathophysiological functions of angiotensinogen have been discovered in the last two decades including kidney developmental abnormalities, atherosclerosis, and obesity. Despite the impressive advance in the understanding of angiotensinogen gene structure and protein functions, some fundamental questions remain unanswered. In this short review, we provide contemporary insights into the molecular characteristics of angiotensinogen and its pathophysiological features. In light of the recent progress, we emphasize some newly recognized functional features of angiotensinogen other than its regulation on blood pressure.
Congqing Wu; Hong Lu; Lisa A Cassis; Alan Daugherty
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Publication Detail:
Journal Detail:
Title:  North American journal of medicine & science     Volume:  4     ISSN:  2156-2342     ISO Abbreviation:  N Am J Med Sci (Boston)     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531232     Medline TA:  N Am J Med Sci (Boston)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  183-190     Citation Subset:  -    
Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA.
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Grant Support
P01 HL080100-05//NHLBI NIH HHS; R01 HL062846-08//NHLBI NIH HHS

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