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Molecular Mechanisms Linking Endometriosis Under Oxidative Stress With Ovarian Tumorigenesis and Therapeutic Modalities.
MedLine Citation:
PMID:  22530740     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression of ARID1A, PIK3CA, and NF-kB genes has been recognized as the major target genes involved in oxidative stress-induced carcinogenesis. HNF-1beta appears to play a key role in anti-oxidative defense mechanisms. We discuss the pathophysiologic roles of oxidative stress as somatic mutations as well as highly specific agents that effectively modulate these targets.
Authors:
Hiroshi Shigetomi; Taihei Tsunemi; Shoji Haruta; Hirotaka Kajihara; Yoriko Yoshizawa; Yasuhito Tanase; Naoto Furukawa; Shozo Yoshida; Toshiyuki Sado; Hiroshi Kobayashi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-25
Journal Detail:
Title:  Cancer investigation     Volume:  -     ISSN:  1532-4192     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Nara Medical University , Nara , Japan.
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