| Molecular Mechanisms of Inflammation During Exacerbations of Chronic Obstructive Pulmonary Disease. | |
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MedLine Citation:
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PMID: 21454005 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is characterised by an inflammatory and systemic response that increases during exacerbations of the disease (ECOPD), although the mechanisms of this inflammatory process are not well known. OBJECTIVES: To explore the inflammatory changes and possible mechanisms during ECOPD. METHODS: We determined the inflammatory cell concentrations in blood and sputum, nitric oxide in exhaled air (FeNO), reactive C-reactive protein (CRP) in plasma, cytokines (IL-6, 8, 1β, 10, 12, TNF-α) and SLPI and total antioxidant activity (TAS) in blood and sputum, the activity of nuclear kappa B factor (NF-kB) and of the histone deacetylase enzymes (HDAC) in 17 patients during ECOPD, in stable phase and in 17 smoking controls and 11 non- smoking. RESULTS: ECOPD is characterised by higher levels of FeNO (P<.05), plasma CRP (P<.001) and IL-8, IL-1B, IL-10 in sputum (P<.05) compared with stable COPD and controls. The TAS levels in sputum were lower in the exacerbated than in stable phase (P<.05) although significantly higher than the controls (P<.05). These findings were accompanied by a greater activation of NF-kB in sputum macrophages during the ECOPD with no changes in the HDAC activity or in the number of neutrophils in sputum, and a statistically significant deterioration (P<.05) of lung function. CONCLUSIONS: Changes were observed in different pulmonary and systemic inflammatory markers during ECOPD, that were not completely resolved during stability. However, current treatment does not allow the modification of HDAC activity, which limits its anti-inflammatory effects. |
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Authors:
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Ana L Kersul; Amanda Iglesias; Angel Ríos; Aina Noguera; Aina Forteza; Enrique Serra; Alvar Agustí; Borja G Cosío |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-29 |
Journal Detail:
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Title: Archivos de bronconeumologia Volume: - ISSN: 1579-2129 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-4-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354720 Medline TA: Arch Bronconeumol Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 SEPAR. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Neumología, Hospital Universitario Son Dureta, Palma de Mallorca, España. |
Vernacular Title:
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Mecanismos moleculares de inflamación durante las agudizaciones de la enfermedad pulmonar obstructiva crónica. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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