Document Detail


Molecular mechanisms guiding embryonic mammary gland development.
MedLine Citation:
PMID:  20484386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mammary gland is an epidermal appendage that begins to form during embryogenesis, but whose development is only completed during pregnancy. Each mammary gland begins as a budlike invagination of the surface ectoderm, which then gives rise to a simple duct system by birth. Subsequent development occurs during sexual maturation and during pregnancy and lactation. In this review, we outline the distinct stages of embryonic mammary development and discuss the molecular pathways involved in the regulation of morphogenesis at each stage. We also discuss the potential relevance of embryonic breast development to the pathophysiology of breast cancer and highlight questions for future research.
Authors:
Pamela Cowin; John Wysolmerski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-05-19
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  2     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-09-08     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a003251     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Lineage
Female
Gene Expression Regulation, Developmental / physiology
Mammary Glands, Animal / cytology,  embryology*,  metabolism
Grant Support
ID/Acronym/Agency:
CA129905/CA/NCI NIH HHS; DK055501/DK/NIDDK NIH HHS; DK069542/DK/NIDDK NIH HHS; DK073941/DK/NIDDK NIH HHS; R01 DK055501/DK/NIDDK NIH HHS
Comments/Corrections

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