| The molecular mechanisms of cervical ripening differ between term and preterm birth. | |
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MedLine Citation:
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PMID: 21209014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the current study, the mechanisms of premature cervical ripening in murine models of preterm birth resulting from infection or early progesterone withdrawal were compared with the process of term cervical ripening. Tissue morphology, weight, gene expression, and collagen content along with immune cell populations were evaluated. Premature ripening induced by the progesterone receptor antagonist mifepristone results from an acceleration of processes in place during term ripening as well as partial activation of proinflammatory and immunosuppressive processes observed during postpartum repair. In contrast to term or mifepristone-induced preterm ripening, premature ripening induced in an infection model occurs by a distinct mechanism which is dominated by an influx of neutrophils into the cervix, a robust proinflammatory response and increased expression of prostaglandin-cyclooxygenase-endoperoxide synthase 2, important in prostaglandin biosynthesis. Key findings from this study confirm that cervical ripening can be initiated by more than one mechanism and is not necessarily an acceleration of the physiologic process at term. These results will influence current strategies for identifying specific etiologies of preterm birth and developing subsequent therapies. |
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Authors:
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Roxane Holt; Brenda C Timmons; Yucel Akgul; Meredith L Akins; Mala Mahendroo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-05 |
Journal Detail:
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Title: Endocrinology Volume: 152 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-22 Completed Date: 2011-04-27 Revised Date: 2012-09-20 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 1036-46 Citation Subset: AIM; IM |
Affiliation:
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Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cervical Ripening / drug effects, physiology* Cervix Uteri / pathology Female Gene Expression Regulation / physiology Hormone Antagonists / pharmacology Lipopolysaccharides / toxicity Mice Mifepristone / pharmacology Pregnancy Premature Birth* Reverse Transcriptase Polymerase Chain Reaction |
| Grant Support | |
ID/Acronym/Agency:
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P01 HD011149/HD/NICHD NIH HHS; R01 HD043154/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hormone Antagonists; 0/Lipopolysaccharides; 84371-65-3/Mifepristone |
| Comments/Corrections | |
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