Document Detail


The molecular mechanisms of cervical ripening differ between term and preterm birth.
MedLine Citation:
PMID:  21209014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the current study, the mechanisms of premature cervical ripening in murine models of preterm birth resulting from infection or early progesterone withdrawal were compared with the process of term cervical ripening. Tissue morphology, weight, gene expression, and collagen content along with immune cell populations were evaluated. Premature ripening induced by the progesterone receptor antagonist mifepristone results from an acceleration of processes in place during term ripening as well as partial activation of proinflammatory and immunosuppressive processes observed during postpartum repair. In contrast to term or mifepristone-induced preterm ripening, premature ripening induced in an infection model occurs by a distinct mechanism which is dominated by an influx of neutrophils into the cervix, a robust proinflammatory response and increased expression of prostaglandin-cyclooxygenase-endoperoxide synthase 2, important in prostaglandin biosynthesis. Key findings from this study confirm that cervical ripening can be initiated by more than one mechanism and is not necessarily an acceleration of the physiologic process at term. These results will influence current strategies for identifying specific etiologies of preterm birth and developing subsequent therapies.
Authors:
Roxane Holt; Brenda C Timmons; Yucel Akgul; Meredith L Akins; Mala Mahendroo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-05
Journal Detail:
Title:  Endocrinology     Volume:  152     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-04-27     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1036-46     Citation Subset:  AIM; IM    
Affiliation:
Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9032, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cervical Ripening / drug effects,  physiology*
Cervix Uteri / pathology
Female
Gene Expression Regulation / physiology
Hormone Antagonists / pharmacology
Lipopolysaccharides / toxicity
Mice
Mifepristone / pharmacology
Pregnancy
Premature Birth*
Reverse Transcriptase Polymerase Chain Reaction
Grant Support
ID/Acronym/Agency:
P01 HD011149/HD/NICHD NIH HHS; R01 HD043154/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Hormone Antagonists; 0/Lipopolysaccharides; 84371-65-3/Mifepristone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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