| Molecular MRI of intracranial thrombus in a rat ischemic stroke model. | |
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MedLine Citation:
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PMID: 20395615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Intracranial thrombus is a principal feature in most ischemic stroke, and thrombus location and size may correlate with outcome and response to thrombolytic therapy. EP-2104R is a fibrin-specific molecular MR agent that has previously been shown to enhance extracranial and venous sinus thrombi in animal models and, recently, in clinical trials. In this study, we examined whether this fibrin-specific MR probe could noninvasively characterize intracranial arterial thrombi. METHODS: Embolic stroke was induced in adult rats by occlusion of the right internal carotid artery with an aged thrombus. We used diffusion-weighted imaging, time of flight angiography, and high-resolution 3-dimensional T1-weighted MRI at 4.7 T before and after use of contrast agents EP-2104R (n=6) and gadopentetate dimeglumine (n=5). RESULTS: In all animals, MR angiography revealed a flow deficit and diffusion-weighted imaging showed hyperintensity consistent with ischemia. Using EP-2104R-enhanced MRI, we saw occlusive thrombi and vessel wall enhancement in all 6 animals with high contrast to noise relative to blood, whereas gadopentetate dimeglumine-injected animals showed no occlusive thrombus or vessel wall enhancement. The concentration of gadolinium in the thrombus after EP-2104R was 18 times that in the blood pool. CONCLUSIONS: EP-2104R-enhanced MRI successfully identifies intracranial thrombus in a rat embolic stroke model. |
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Authors:
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Ritika Uppal; Ilknur Ay; Guangping Dai; Young Ro Kim; A Gregory Sorensen; Peter Caravan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-15 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-25 Completed Date: 2010-06-11 Revised Date: 2012-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 1271-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Massachusetts General Hospital-East, 149 13th Street, Suite 2301, Charlestown, MA 02129, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / radiography* Contrast Media / pharmacology* Disease Models, Animal Gadolinium / pharmacology* Intracranial Thrombosis / radiography* Magnetic Resonance Angiography / methods* Male Peptides / pharmacology* Rats Rats, Wistar Stroke / radiography* Thrombolytic Therapy |
| Grant Support | |
ID/Acronym/Agency:
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5T32CA009502/CA/NCI NIH HHS; EB009062/EB/NIBIB NIH HHS; NS38477/NS/NINDS NIH HHS; P41 RR014075-11/RR/NCRR NIH HHS; P41-RR14075/RR/NCRR NIH HHS; R01 EB009062/EB/NIBIB NIH HHS; R01 EB009062-01A1/EB/NIBIB NIH HHS; R01 EB009062-03/EB/NIBIB NIH HHS; R01 NS038477-10/NS/NINDS NIH HHS; T32 CA009502-20/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/EP-2104R; 0/Peptides; 7440-54-2/Gadolinium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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