| Molecular MRI of Inflammation in Atherosclerosis. | |
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MedLine Citation:
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PMID: 22308200 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Inflammatory activity in atherosclerotic plaque is a risk factor for plaque rupture and atherothrombosis and may direct interventional therapy. Inflammatory activity can be evaluated at the (sub)cellular level using in vivo molecular MRI. This paper reviews recent progress in contrast-enhanced molecular MRI to visualize atherosclerotic plaque inflammation. Various MRI contrast agents, among others ultra-small particles of iron oxide, low-molecular-weight Gd-chelates, micelles, liposomes, and perfluorocarbon emulsions, have been used for in vivo visualization of various inflammation-related targets, such as macrophages, oxidized LDL, endothelial cell expression, plaque neovasculature, MMPs, apoptosis, and activated platelets/thrombus. An enzyme-activatable magnetic resonance contrast agent has been developed to study myeloperoxidase activity in inflamed plaques. Agents creating contrast based on the chemical exchange saturation transfer mechanism were used for thrombus imaging. Transfer of these molecular MRI techniques to the clinic will critically depend on the safety profiles of these newly developed magnetic resonance contrast agents. |
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Authors:
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Bernard C Te Boekhorst; Geralda A van Tilborg; Gustav J Strijkers; Klaas Nicolay |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-5 |
Journal Detail:
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Title: Current cardiovascular imaging reports Volume: 5 ISSN: 1941-9074 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101484775 Medline TA: Curr Cardiovasc Imaging Rep Country: - |
Other Details:
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Languages: ENG Pagination: 60-68 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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