| Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake. | |
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MedLine Citation:
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PMID: 20685878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxytocin (OT) facilitates feeding termination stemming from high osmolality, stomach distention, and malaise. Recent knockout (KO) studies suggested a crucial function for OT in carbohydrate intake: OT-/- mice had increased preference for carbohydrates, including sucrose, but not fat (Intralipid). In striking contrast, sugar appetite was unaffected in the OT receptor KO mouse; data from wild-type animals have been insufficient. Therefore, we examined the involvement of OT in the regulation of sucrose vs. fat intake in C57BL/6 mice that served as a background KO strain. We exposed mice to a meal of sucrose or Intralipid and determined that the percentage of c-Fos-immunoreactive paraventricular hypothalamic OT neurons was elevated at termination of intake of either of the tastants, but this increase was 2-fold higher in sucrose-fed mice. A 48-h exposure to sucrose compared with Intralipid caused up-regulation of OT mRNA, whereas inherent individual preferences for sucrose vs. fat were not associated with differences in baseline OT expression as established with quantitative PCR. We found that L-368,899, an OT receptor antagonist, increased sugar intake when sucrose was presented alone or concurrently with Intralipid; it had no effect on Intralipid or total calorie consumption. L-368,899 affected Fos immunoreactivity in the paraventricular hypothalamus, arcuate nucleus, amygdala, and nucleus of the solitary tract, areas involved in aversion, satiety, and reward. This pattern serves as neuroanatomical basis of OT's complex role in food intake, including sucrose intake. The current findings expand our knowledge on OT and suggest that it acts as a carbohydrate-specific inhibitor of feeding. |
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Authors:
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Pawel K Olszewski; Anica Klockars; Agnieszka M Olszewska; Robert Fredriksson; Helgi B Schiöth; Allen S Levine |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-04 |
Journal Detail:
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Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2010-11-04 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 4736-44 Citation Subset: AIM; IM |
Affiliation:
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Minnesota Obesity Center, University of Minnesota, Department of Food Science and Nutrition, 1334 Eckles Avenue, Saint Paul, Minnesota 55108, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation* / drug effects, genetics Bornanes / pharmacology Dietary Carbohydrates* / administration & dosage, metabolism Dietary Fats* / administration & dosage, metabolism Down-Regulation / drug effects Eating / drug effects, genetics, physiology Feeding Behavior / drug effects, physiology Hormone Antagonists / pharmacology Immunohistochemistry Male Mice Mice, Inbred C57BL Mice, Knockout Oxytocin / genetics*, metabolism, pharmacology*, physiology* Piperazines / pharmacology Receptors, Oxytocin / antagonists & inhibitors |
| Grant Support | |
ID/Acronym/Agency:
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P30DK50456/DK/NIDDK NIH HHS; R01DA021280/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bornanes; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Hormone Antagonists; 0/Piperazines; 0/Receptors, Oxytocin; 148927-60-0/L 368899; 50-56-6/Oxytocin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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