Document Detail


Molecular findings in childhood leukemia in Brazil: high frequency of MLL-ENL Fusion/t(11;19) in infant leukemia.
MedLine Citation:
PMID:  21436736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Translocations involving chromosome 11q23 are frequently found in pediatric leukemia, especially in infants. The mixed lineage leukemia (MLL)-AF4 fusion/t(4;11) is mostly found in acute lymphoblastic leukemia (ALL) and MLL-AF9 fusion/t(9;11) in acute myeloid leukemia (AML). We study 441 consecutive new cases of childhood leukemia diagnosed in Brazil. Chromosomal translocation was determined solely by conventional polymerase chain reaction (PCR) in 72 out of 265 ALL and in 43 out of 103 AML. MLL-AF4 fusion/t(4;11) was detected in 3 out of 265 ALL and MLL-AF9 fusion/t(9;11) in 4 out of 103 of AML. MLL-rearrangements were presented in 7 out of 23 infant leukemia, whose 5 were MLL-ENL fusion/t(11;19). No fusion MLL-AF4 fusion/t(4;11) was found. Other translocation frequencies differed from that reported for an American population suggesting interethnic differences on chromosomal translocations frequencies in acute leukemia.
Authors:
Ester Augusta Lima Vinhas Marques; Lidia Neves; Tereza Cristina Fonseca; Mecneide Mendes Lins; Francisco Pedrosa; Norma Lucena-Silva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  33     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-27     Completed Date:  2011-09-27     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-4     Citation Subset:  IM    
Affiliation:
Pediatric Oncology Service/IMIP Hospital, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brazil
Child
Child, Preschool
Chromosomes, Human, Pair 11 / genetics*
Chromosomes, Human, Pair 9 / genetics*
Female
Humans
Infant
Infant, Newborn
Leukemia, Myeloid, Acute / diagnosis,  genetics*
Male
Myeloid-Lymphoid Leukemia Protein / genetics*
Oncogene Proteins, Fusion / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis,  genetics*
Prognosis
Survival Rate
Translocation, Genetic / genetics*
Chemical
Reg. No./Substance:
0/MLL-ELL fusion protein, human; 0/Oncogene Proteins, Fusion; 149025-06-9/Myeloid-Lymphoid Leukemia Protein

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