Document Detail


Molecular Evolution of Translin Superfamily Proteins Within the Genomes of Eubacteria, Archaea and Eukaryotes.
MedLine Citation:
PMID:  23188094     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Translin and its interacting partner protein, TRAX, are members of the translin superfamily. These proteins are involved in mRNA regulation and in promoting RISC activity by removing siRNA passenger strand cleavage products, and have been proposed to play roles in DNA repair and recombination. Both homomeric translin and heteromeric translin-TRAX complex bind to ssDNA and RNA; however, the heteromeric complex is a key activator in siRNA-mediated silencing in human and drosophila. The residues critical for RNase activity of the complex reside in TRAX sequence. Both translin and TRAX are well conserved in eukaryotes. In present work, a single translin superfamily protein is detected in Chloroflexi eubacteria, in the known phyla of archaea and in some unicellular eukaryotes. The prokaryotic proteins essentially share unique sequence motifs with eukaryotic TRAX, while the proteins possessing both the unique sequences and conserved indels of TRAX or translin can be identified from protists. Intriguingly, TRAX protein in all the known genomes of extant Chloroflexi share high sequence similarity and conserved indels with the archaeal protein, suggesting occurrence of TRAX at least at the time of Chloroflexi divergence as well as evolutionary relationship between Chloroflexi and archaea. The mirror phylogeny in phylogenetic tree, constructed using diverse translin and TRAX sequences, indicates gene duplication event leading to evolution of translin in unicellular eukaryotes, prior to divergence of multicellular eukayrotes. Since Chloroflexi has been debated to be near the last universal common ancestor, the present analysis indicates that TRAX may be useful to understand the tree of life.
Authors:
Gagan D Gupta; Avinash Kale; Vinay Kumar
Related Documents :
9767684 - Biased usages of arginines and lysines in proteins are correlated with local-scale fluc...
24421334 - Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.
24089564 - Cytoplasmic granule formation and translational inhibition of nodaviral rnas in the abs...
23670274 - Replacement of the c6orf66 assembly factor (ndufaf4) restores complex i activity in pat...
20026484 - Evolutionary expansion and specialization of the pdz domains.
14871934 - Adam family protein mde10 is essential for development of spore envelopes in the fissio...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-28
Journal Detail:
Title:  Journal of molecular evolution     Volume:  -     ISSN:  1432-1432     ISO Abbreviation:  J. Mol. Evol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0360051     Medline TA:  J Mol Evol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
High Pressure & Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxyg...
Next Document:  Evaluation of experimental pain tests to predict labour pain and epidural analgesic consumption.