Document Detail


Molecular conversations and the development of the hair follicle and basal cell carcinoma.
MedLine Citation:
PMID:  20858758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The understanding of the anatomy and development of fetal and adult hair follicles and the molecular study of the major embryonic pathways that regulate the hair follicle have led to exciting discoveries concerning the development of basal cell carcinoma (BCC). These studies have shed light on the major roles of Sonic hedgehog (Shh) signaling and its interactions with the insulin-like growth factor (IGF) axis in BCC development. New work, for example, explores a link between Shh signaling and IGF binding protein-2 (IGFBP-2) in the hair follicle as it transforms into BCC. IGFBP-2 was overexpressed in specific hair follicle cells of mice with ectopically activated Shh signaling [keratin 14 (K14)-Cre: patched homologue 1 (Cre: Ptch1)(lox/lox) mice]. Ptch1 deletion resulted in both an expansion of the stem cell niche and inhibition of cell differentiation. In transformed hair follicles, IGFBP-2 mediates epidermal progenitor cell expansion. Evidence also indicated that IGFBP-2 is expressed in human BCC.
Authors:
Pamela Jo Harris; Naoko Takebe; S Percy Ivy
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-09-21
Journal Detail:
Title:  Cancer prevention research (Philadelphia, Pa.)     Volume:  3     ISSN:  1940-6215     ISO Abbreviation:  Cancer Prev Res (Phila)     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2011-01-25     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  101479409     Medline TA:  Cancer Prev Res (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1217-21     Citation Subset:  IM    
Copyright Information:
©2010 AACR.
Affiliation:
Cancer Therapy Evaluation Program, National Cancer Institute, NIH, Bethesda, Maryland 20892-7426, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Basal Cell / genetics,  metabolism,  pathology*
Cell Transformation, Neoplastic* / genetics,  metabolism
Hair Follicle / embryology,  growth & development*,  metabolism
Hedgehog Proteins / genetics,  metabolism
Humans
Insulin-Like Growth Factor Binding Protein 2 / genetics,  metabolism
Signal Transduction / physiology*
Skin Neoplasms / genetics,  metabolism,  pathology*
Chemical
Reg. No./Substance:
0/Hedgehog Proteins; 0/Insulin-Like Growth Factor Binding Protein 2
Comments/Corrections

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