Document Detail


Molecular convergence of infrared vision in snakes.
MedLine Citation:
PMID:  20937734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been discovered that the transient receptor potential ankyrin 1 (TRPA1) proteins of Boidae (boas), Pythonidae (pythons), and Crotalinae (pit vipers) are used to detect infrared radiation, but the molecular mechanism for detecting the infrared radiation is unknown. Here, relating the amino acid substitutions in their TRPA1 proteins and the functional differentiations, we propose that three parallel amino acid changes (L330M, Q391H, and S434T) are responsible for the development of infrared vision in the three groups of snakes. Protein modeling shows that the three amino acid changes alter the structures of the central region of their ankyrin repeats.
Authors:
Shozo Yokoyama; Ahmet Altun; Dale F DeNardo
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Publication Detail:
Type:  Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-11
Journal Detail:
Title:  Molecular biology and evolution     Volume:  28     ISSN:  1537-1719     ISO Abbreviation:  Mol. Biol. Evol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-03-28     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8501455     Medline TA:  Mol Biol Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Amino Acid Substitution
Animals
Boidae / physiology*
Evolution, Molecular
Humans
Infrared Rays*
Models, Molecular
Molecular Sequence Data
Phylogeny
Protein Structure, Tertiary
Sequence Alignment
Transient Receptor Potential Channels / chemistry,  classification,  genetics*,  metabolism
Viperidae / physiology*
Vision, Ocular / physiology*
Grant Support
ID/Acronym/Agency:
R01EY016400/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Transient Receptor Potential Channels
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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