Document Detail


Molecular characteristics of occult hepatitis B virus from blood donors in southeast China.
MedLine Citation:
PMID:  19940057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg(+)) group (P < 0.001). Specific amino acid substitutions in the regions from amino acids 117 to 121 and amino acids 144 to 147 located in the major hydrophilic region of the S gene were associated with carriers with OBIs (P < 0.01 for carriers with OBIs versus HBsAg(+) donors, carriers with OBIs versus HBsAg(+) asymptomatic carriers, and carriers with OBIs versus HBsAg(+) chronic hepatitis patients). G145R was the major variation in the HBV isolates responsible for local occult HBV infections.
Authors:
Quan Yuan; Shan-Hai Ou; Chang-Rong Chen; Sheng-Xiang Ge; Bin Pei; Qing-Rui Chen; Qiang Yan; Yong-Cai Lin; Hong-Ying Ni; Cheng-Hao Huang; Anthony E T Yeo; James W K Shih; Jun Zhang; Ning-Shao Xia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-25
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  48     ISSN:  1098-660X     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-29     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-62     Citation Subset:  IM    
Affiliation:
National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Science, Xiamen University, Xiamen, Fujian Province, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Sequence
Amino Acid Substitution
Blood Donors*
Carrier State / virology*
China
DNA, Viral / genetics
Female
Genotype
Hepatitis B / virology*
Hepatitis B Surface Antigens / genetics
Hepatitis B virus / genetics*,  isolation & purification*
Hepatitis B, Chronic / virology
Humans
Male
Molecular Sequence Data
Mutation, Missense
Sequence Analysis, DNA
Young Adult
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Hepatitis B Surface Antigens
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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