Document Detail


Molecular changes occurring during reverse remodelling following left ventricular assist device support.
MedLine Citation:
PMID:  20820974     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Remodelling is the central feature that occurs in the progression of heart failure. However, unloading of the heart with a left ventricular assist device (LVAD) can lead to reversal of many of the remodelling changes even in patients with advanced heart failure. LVAD unloading can also lead to improved myocardial function and this improvement can be sufficient to allow removal of the device leaving the patient to lead a normal life. We review the molecular changes that have been demonstrated with LVAD unloading in patients bridged to transplantation and also those that have occurred in the myocardium of patients that have recovered their myocardial function enough to have the device removed. Changes in both the myocyte and the matrix are reviewed.
Authors:
Emma J Birks; Robert S George
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Publication Detail:
Type:  Journal Article     Date:  2010-09-04
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  3     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  635-42     Citation Subset:  IM    
Affiliation:
Transplantation and Mechanical Support, University of Louisville, 201 Abraham Flexner Way, Louisville, KY 40222, USA. e.birks@imperial.ac.uk
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