| Molecular Biology of Myelodysplastic Syndromes. | |
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MedLine Citation:
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PMID: 21943667 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Myelodysplastic syndromes (MDS) are a group of clonal hematopoetic disorders marked by ineffective hematopoiesis, peripheral cytopenias, and an increased risk of transformation to acute myeloid leukemia. Multiple processes govern hematopoietic progenitor proliferation and natural differentiation into mature myeloid elements. Molecular events that disrupt any of these processes have the potential to lead to ineffective hematopoiesis and an MDS phenotype. Recent advances in genomic analysis have identified a number of new genes that may be involved. The molecular description of MDS will lead to better understanding, classification, and treatment of this disease. |
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Authors:
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Alan H Shih; Ross L Levine |
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Publication Detail:
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Type: - |
Journal Detail:
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Title: Seminars in oncology Volume: 38 ISSN: 1532-8708 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0420432 Medline TA: Semin Oncol Country: - |
Other Details:
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Languages: ENG Pagination: 613-620 Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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