| Molecular Biology of the Cell Cycle: Potential for Therapeutic Applications in Radiation Oncology. | |
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MedLine Citation:
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PMID: 10717186 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The cell cycle was first described by radiation biologists more than 40 years ago. Since then, radiation oncologists have used information regarding the cell cycle, in particular cell cycle kinetics, to design various treatment protocols; these have resulted in only modest improvements in patient outcome. Over the past 10 to 15 years there has been an explosion of scientific knowledge regarding the cell cycle, in particular the molecular regulation of the cell cycle checkpoints. In this review we will discuss the genetic events involved in regulating the G1 and G2 checkpoints and how this information may lead to future therapeutic breakthroughs. In addition we will discuss the potential clinical impact of the recent cloning of the gene for ataxia telangiectasia. |
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Authors:
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Rudoltz; Kao; Blank; Muschel; McKenna |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Seminars in radiation oncology Volume: 6 ISSN: 1532-9461 ISO Abbreviation: Semin Radiat Oncol Publication Date: 1996 Oct |
Date Detail:
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Created Date: 2000-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9202882 Medline TA: Semin Radiat Oncol Country: - |
Other Details:
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Languages: ENG Pagination: 284-294 Citation Subset: - |
Affiliation:
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Department of Radiation Oncology and Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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