Document Detail

The molecular basis of memory. Part 2: chemistry of the tripartite mechanism.
MedLine Citation:
PMID:  23419130     Owner:  NLM     Status:  MEDLINE    
We propose a tripartite mechanism to describe the processing of cognitive information (cog-info), comprising the (1) neuron, (2) surrounding neural extracellular matrix (nECM), and (3) numerous "trace" metals distributed therein. The neuron is encased in a polyanionic nECM lattice doped with metals (>10), wherein it processes (computes) and stores cog-info. Each [nECM:metal] complex is the molecular correlate of a cognitive unit of information (cuinfo), similar to a computer "bit". These are induced/sensed by the neuron via surface iontophoretic and electroelastic (piezoelectric) sensors. The generic cuinfo are used by neurons to biochemically encode and store cog-info in a rapid, energy efficient, but computationally expansive manner. Here, we describe chemical reactions involved in various processes that underline the tripartite mechanism. In addition, we present novel iconographic representations of various types of cuinfo resulting from"tagging" and cross-linking reactions, essential for the indexing cuinfo for organized retrieval and storage of memory.
Gerard Marx; Chaim Gilon
Publication Detail:
Type:  Journal Article; Review     Date:  2013-03-21
Journal Detail:
Title:  ACS chemical neuroscience     Volume:  4     ISSN:  1948-7193     ISO Abbreviation:  ACS Chem Neurosci     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-09-12     Completed Date:  2014-01-28     Revised Date:  2014-06-25    
Medline Journal Info:
Nlm Unique ID:  101525337     Medline TA:  ACS Chem Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  983-93     Citation Subset:  IM    
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MeSH Terms
Brain Chemistry / physiology*
Cognition / physiology
Extracellular Matrix / chemistry,  metabolism
Hippocampus / chemistry*,  metabolism*
Memory / physiology*
Trace Elements / chemistry,  metabolism*
Reg. No./Substance:
0/Trace Elements

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