| Molecular analysis of a case of nevus of ota showing progressive evolution to melanoma with intermediate stages resembling cellular blue nevus. | |
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MedLine Citation:
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PMID: 20110797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nevus of Ota is a variant of congenital nevus, which is morphologically paucicellular and resembles a common blue nevus. Although nevus of Ota is a risk factor for uveal melanoma in white people, the development of cutaneous melanoma within nevus of Ota is a very rare occurrence with only a few reported cases. We present a case of a long-standing nevus of Ota, with radiologic imaging demonstrating a large retro-orbital mass and a biopsy showing melanoma. The histopathology of the eye exenteration specimen illustrated various stages of melanocytic progression including areas resembling a nevus of Ota, blue nevus, cellular blue nevus, and melanoma. There was heterogeneity in the overtly malignant sections with some areas displaying expansile nodules of blander appearing spindled cells, whereas other areas were composed of epithelioid cells with higher mitotic counts and zones of necrosis. The extensive lesion also infiltrated the soft tissue and bone. We performed gene mutation analysis for GNAQ, BRAF, NRAS, and KIT and fluorescence in situ hybridization (FISH) targeting commonly altered chromosomal loci in melanoma and comparative genomic hybridization (CGH). Copy number changes typical of melanoma were identified by both FISH and CGH in the morphologically malignant areas illustrating the relationship of tumor progression and the progressive acquisition of genetic aberrations. |
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Authors:
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Pedram Gerami; Pedram Pouryazdanparast; Swapna Vemula; Boris C Bastian |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 32 ISSN: 1533-0311 ISO Abbreviation: Am J Dermatopathol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
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Languages: eng Pagination: 301-5 Citation Subset: IM |
Affiliation:
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Dermatology and daggerPathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. pgerami@nmff.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Comparative Genomic Hybridization DNA Mutational Analysis DNA, Neoplasm / analysis Disease Progression Female Humans In Situ Hybridization, Fluorescence Melanoma / genetics, pathology*, therapy Middle Aged Nevus of Ota / genetics, pathology*, therapy Nevus, Blue / genetics, pathology*, therapy Orbit Evisceration Orbital Neoplasms / genetics, pathology*, therapy Radiotherapy, Adjuvant Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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