| Molecular adaptations to aerobic exercise training in skeletal muscle of older women. | |
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MedLine Citation:
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PMID: 20566734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We have recently shown that 12 weeks of progressive aerobic exercise training improves whole-muscle size and function in older women. The purpose of this investigation was to evaluate molecular markers that may be associated with muscle hypertrophy after aerobic training in aging skeletal muscle. METHODS: Muscle biopsies were obtained before and after 12 weeks of aerobic exercise training on a cycle ergometer in nine older women (70 ± 2 years) to determine basal levels of messenger RNA and protein content of select myogenic, proteolytic, and mitochondrial factors. RESULTS: The training program increased (p < .05) aerobic capacity 30 ± 9%, whole-muscle cross-sectional area 11 ± 2%, and whole-muscle force production 29 ± 8%. Basal messenger RNA levels of FOXO3A, myostatin, HSP70, and MRF4 were lower (p < .05) after aerobic training. FOXO3A, FOXO3A phosphorylation, and HSP70 protein content were unaltered after training. Mitochondrial protein COX IV was elevated (p < .05) 33 ± 7% after aerobic training, whereas PGC-1α protein content was 20 ± 5% lower (p < .05). CONCLUSIONS: These data suggest that reductions in FOXO3A and myostatin messenger RNA are potentially associated with exercise-induced muscle hypertrophy. Additionally, it appears that mitochondrial biogenesis can occur with aerobic training in older women independent of increased PGC-1α protein. Aerobic exercise training alters molecular factors related to the regulation of skeletal muscle, which supports the beneficial role of aerobic training for improving muscle health in older women. |
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Authors:
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Adam R Konopka; Matthew D Douglass; Leonard A Kaminsky; Bozena Jemiolo; Todd A Trappe; Scott Trappe; Matthew P Harber |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-21 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 65 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-14 Completed Date: 2010-11-16 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1201-7 Citation Subset: AIM; IM |
Affiliation:
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Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Aged Biological Markers / metabolism Biopsy Blotting, Western Body Composition Exercise / physiology* Female Forkhead Transcription Factors / metabolism Gene Expression HSP70 Heat-Shock Proteins / metabolism Heat-Shock Proteins / metabolism Humans Mitochondria / metabolism Muscle Strength / physiology Muscle, Skeletal / metabolism, physiology* Myostatin / metabolism Oxygen Consumption / physiology Phosphorylation RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Transcription Factors / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AG32127/AG/NIA NIH HHS; R15 AG032127-01A2/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FOXO3 protein, human; 0/Forkhead Transcription Factors; 0/HSP70 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/MSTN protein, human; 0/Myostatin; 0/PPARGC1A protein, human; 0/RNA, Messenger; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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