Document Detail


Molecular adaptations to aerobic exercise training in skeletal muscle of older women.
MedLine Citation:
PMID:  20566734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We have recently shown that 12 weeks of progressive aerobic exercise training improves whole-muscle size and function in older women. The purpose of this investigation was to evaluate molecular markers that may be associated with muscle hypertrophy after aerobic training in aging skeletal muscle.
METHODS: Muscle biopsies were obtained before and after 12 weeks of aerobic exercise training on a cycle ergometer in nine older women (70 ± 2 years) to determine basal levels of messenger RNA and protein content of select myogenic, proteolytic, and mitochondrial factors.
RESULTS: The training program increased (p < .05) aerobic capacity 30 ± 9%, whole-muscle cross-sectional area 11 ± 2%, and whole-muscle force production 29 ± 8%. Basal messenger RNA levels of FOXO3A, myostatin, HSP70, and MRF4 were lower (p < .05) after aerobic training. FOXO3A, FOXO3A phosphorylation, and HSP70 protein content were unaltered after training. Mitochondrial protein COX IV was elevated (p < .05) 33 ± 7% after aerobic training, whereas PGC-1α protein content was 20 ± 5% lower (p < .05).
CONCLUSIONS: These data suggest that reductions in FOXO3A and myostatin messenger RNA are potentially associated with exercise-induced muscle hypertrophy. Additionally, it appears that mitochondrial biogenesis can occur with aerobic training in older women independent of increased PGC-1α protein. Aerobic exercise training alters molecular factors related to the regulation of skeletal muscle, which supports the beneficial role of aerobic training for improving muscle health in older women.
Authors:
Adam R Konopka; Matthew D Douglass; Leonard A Kaminsky; Bozena Jemiolo; Todd A Trappe; Scott Trappe; Matthew P Harber
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-06-21
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  65     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2010-11-16     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1201-7     Citation Subset:  AIM; IM    
Affiliation:
Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Aged
Biological Markers / metabolism
Biopsy
Blotting, Western
Body Composition
Exercise / physiology*
Female
Forkhead Transcription Factors / metabolism
Gene Expression
HSP70 Heat-Shock Proteins / metabolism
Heat-Shock Proteins / metabolism
Humans
Mitochondria / metabolism
Muscle Strength / physiology
Muscle, Skeletal / metabolism,  physiology*
Myostatin / metabolism
Oxygen Consumption / physiology
Phosphorylation
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Transcription Factors / metabolism
Grant Support
ID/Acronym/Agency:
AG32127/AG/NIA NIH HHS; R15 AG032127-01A2/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/FOXO3 protein, human; 0/Forkhead Transcription Factors; 0/HSP70 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/MSTN protein, human; 0/Myostatin; 0/PPARGC1A protein, human; 0/RNA, Messenger; 0/Transcription Factors
Comments/Corrections

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