| Molar villous fluid suppresses mononuclear cell cytotoxicity. | |
| | |
MedLine Citation:
|
PMID: 1473743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Complete molar pregnancy tissue is an allograft to the mother because all molar chromosomes are of paternal origin. Interactions between molar tissue and the maternal immune system may be important in the natural history of complete molar pregnancy. Molar villous fluid (MVF) has previously been demonstrated to suppress both mitogen and interleukin-2-induced T lymphocyte proliferation. The current study was undertaken to evaluate the potential effect of MVF on the cytotoxic activity of mononuclear cells (MNC) and lymphokine-activated mononuclear cells (LA-MNC). Sera and molar villous fluid were obtained from four women at the time of molar evacuation. K-562 erythroblastoid cells were used as target cells for MNC-mediated lysis, and JEG-3 choriocarcinoma cells were used as targets for LA-MNC-mediated lysis in a 51Cr release assay. Relative to patient sera, all MVF tested significantly inhibited both MNC and LA-MNC lysis of target cells (48.3 and 91% mean inhibition, respectively; P < 0.05). This study provides additional evidence that molar gestational tissue produces factor(s) that suppress maternal immunologic responses. Potential therapies may become available to reduce or eliminate the immunosuppressive effects of molar gestations resulting in a more favorable clinical outcome in patients with complete molar pregnancy and postmolar gestational trophoblastic tumors. |
| | |
Authors:
|
V Fulop; B B Feinberg; M A Steller; D J Anderson; R S Berkowitz |
Related Documents
:
|
1720883 - Clinical management and diagnostic possibilities in hydatidiform mole with coexistent f... 6097203 - Hepatocellular carcinoma hbsag positive in pregnancy. 3361503 - Co-ordination of electrical activity in the myometrium of pregnant ewes. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Gynecologic oncology Volume: 47 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 1992 Dec |
Date Detail:
|
Created Date: 1993-02-03 Completed Date: 1993-02-03 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 311-6 Citation Subset: IM |
Affiliation:
|
Fearing Research Laboratory, Harvard Medical School, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Choriocarcinoma
/
immunology Cytotoxicity, Immunologic* Female Humans Hydatidiform Mole / immunology* Immune Tolerance Killer Cells, Lymphokine-Activated / immunology Killer Cells, Natural / immunology Leukocytes, Mononuclear / immunology* Pregnancy Uterine Neoplasms / immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
HD23775/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Estrogen and progesterone receptor assay in carcinoma of the cervix with monoclonal antibodies.
Next Document: Steroid receptors in ovarian carcinoma: immunohistochemical determination may lead to new aspects.