Document Detail


Moisturizers, vehicle effects, and photocarcinogenesis.
MedLine Citation:
PMID:  19148213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Topically applied formulations (e.g., emollients and moisturizers) may influence the optical physics of skin and therefore the effectiveness of UVR exposures. In this issue, Lu et al. provide evidence for another type of influence by moisturizers, one that does not require the presence of the chemical agent before or during UVR exposure. Several such test agents applied after the completion of a course of UVR enhanced the tumor response in mice, both qualitatively and quantitatively. The study design is rational but the group sizes are modest, the resulting database is therefore limited, and the repeatability is not yet determined. Perhaps most important for the this Journal's readership, the clinical relevance is unknown and deserves detailed examination.
Authors:
Paul Donald Forbes
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  129     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-2     Citation Subset:  IM    
Affiliation:
Charles River Laboratories, Inc., The Center for Photobiology, 905 Sheehy Drive, Horsham, Pennsylvania 19044, USA. don.forbes@crl.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Dermatologic Agents / adverse effects*
Emollients / adverse effects*
Humans
Skin Neoplasms / etiology*
Ultraviolet Rays / adverse effects*
Chemical
Reg. No./Substance:
0/Dermatologic Agents; 0/Emollients
Comments/Corrections
Comment On:
J Invest Dermatol. 2009 Feb;129(2):468-75   [PMID:  18704106 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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