| Moistening of misoprostol tablets with acetic acid prior to vaginal administration for mid-trimester termination of anomalous pregnancy: A randomised comparison of three regimens. | |
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MedLine Citation:
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PMID: 20063994 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy and side effects of three regimens of intravaginal misoprostol for second-trimester abortion. METHODS: A total of 118 women requiring second-trimester pregnancy termination were randomly assigned to one of three treatment groups: 400 microg 3-hourly in group A (n = 39), 600 microg 6-hourly in group B (n = 39), and 800 microg 12-hourly in group C (n = 40). Misoprostol tablets moistened with 3 ml of 5% acetic acid were placed into the posterior vaginal fornix. RESULTS: The median induction-abortion times in groups A (8 h [range: 3-64]) and B (9 h [4-81]) were significantly shorter (p < 0.01 and p < 0.05, respectively) than in group C (12.5 [3-72]). Moreover, expulsion rates within 24 hours in groups A (92.3%) and B (92.3%) were significantly higher (p < 0.05 in both cases) than that of group C (75%). Expulsion rate within 48 hours, number of tablets used, number of patients with retained placenta and side effects did not differ between groups. CONCLUSIONS: Misoprostol moistened with acetic acid is effective for second-trimester pregnancy termination when given vaginally 3-hourly, 6-hourly or 12-hourly. The former two regimens are significantly more effective than the latter. |
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Authors:
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Bulent Yilmaz; Ibrahim Egemen Ertas; Sefa Kelekci; Necdet Sut; Leyla Mollamahmutoglu; Nuri Danisman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception Volume: 15 ISSN: 1473-0782 ISO Abbreviation: Eur J Contracept Reprod Health Care Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9712127 Medline TA: Eur J Contracept Reprod Health Care Country: England |
Other Details:
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Languages: eng Pagination: 54-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. drbulentyilmaz@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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