Document Detail


Modulatory role of a constitutively active population of alpha(1D)-adrenoceptors in conductance arteries.
MedLine Citation:
PMID:  11788394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A constitutively active population of alpha(1D)-adrenoceptors in iliac and proximal, distal, and small mesenteric rat arteries was studied. The increase in resting tone (IRT) that evidences it was observed only in iliac and proximal mesenteric and was inhibited by prazosin (pIC(50) = 9.57), 5-methylurapidil (pIC(50) = 7.61), and BMY 7378 (pIC(50) = 8.77). Chloroethylchlonidine (100 micromol/l) did not affect IRT, but when added before the other antagonists it blocked their effect. The potency shown by BMY 7378 confirms the alpha(1D)-subtype as responsible for IRT. BMY 7378 displayed greater inhibition of adrenergic responses in iliac (pIC(50) = 7.57 +/- 0.11) and proximal mesenteric arteries (pIC(50) = 8.05 +/- 0.2) than in distal (pIC(50) = 6.94 +/- 0.13) or small mesenteric arteries (pIC(50) = 6.30 +/- 0.14), which confirms the functional role of the alpha(1D)-adrenoceptor in iliac and proximal mesenteric arteries. This subtype prevents abrupt changes in iliac and proximal mesenteric artery caliber when the agonist disappears, and this modulatory role is evidenced by the slower decay in the response to norepinephrine after removal.
Authors:
Khalid Ziani; Regina Gisbert; Maria Antonia Noguera; Maria Dolores Ivorra; Pilar D'Ocon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  282     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-14     Completed Date:  2002-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H475-81     Citation Subset:  IM    
Affiliation:
Departamento de Farmacología, Facultad de Farmacia, Universitat de València, 46100 Burjassot, Valencia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology
Adrenergic alpha-Antagonists / pharmacology
Animals
Aorta / metabolism
Arteries / metabolism*
Calcium / metabolism
Clonidine / analogs & derivatives*,  pharmacology
Dose-Response Relationship, Drug
Female
Iliac Artery / metabolism
Mesenteric Arteries / metabolism
Norepinephrine / pharmacology
Piperazines / pharmacology
Prazosin / pharmacology
Rats
Rats, Wistar
Receptors, Adrenergic, alpha-1 / physiology*
Vascular Resistance / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Piperazines; 0/Receptors, Adrenergic, alpha-1; 19216-56-9/Prazosin; 21102-94-3/BMY 7378; 34661-85-3/5-methylurapidil; 4205-90-7/Clonidine; 51-41-2/Norepinephrine; 7440-70-2/Calcium; 98086-36-3/chlorethylclonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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