| Modulatory effects of testosterone on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. | |
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MedLine Citation:
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PMID: 8263548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either empty Silastic capsules or capsules containing testosterone and subsequently treated with MPTP. A small area of the corpus striatum was removed for determination of dopamine (DA) content, whereas the remainder was superfused and used to measure L-DOPA (5 microM)-evoked DA release. In animals treated with MPTP, L-DOPA-evoked DA release was reduced significantly in CD-1 mice, but not in C57/B1 mice, treated with testosterone. No differences in L-DOPA-stimulated DA release between MPTP-versus vehicle-treated mice was observed in either the CD-1 or C57/B1 mice receiving empty Silastic capsules. Corpus striatum DA contents were more severely depleted in the MPTP-sensitive C57/B1 versus the CD-1 mouse strain irrespective of hormone treatment. These results confirm previous results demonstrating differences in these two mouse strains in response to the neurotoxic effects of MPTP upon corpus striatum DA content. More interestingly, they show an important differential modulatory effect of testosterone upon L-DOPA-evoked DA release as a function of MPTP treatment and indicate that testosterone significantly alters the neurotoxic effects of MPTP in the CD-1 mouse. |
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Authors:
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D Dluzen; R Jain; B Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurochemistry Volume: 62 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-01-24 Completed Date: 1994-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 94-101 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown 44272-0095. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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antagonists & inhibitors Animals Corpus Striatum / drug effects, metabolism* Dopamine / metabolism* Drug Implants Levodopa / pharmacology MPTP Poisoning* Male Mice Mice, Inbred C57BL Mice, Inbred Strains Neurotoxins / antagonists & inhibitors, toxicity* Orchiectomy Parkinson Disease, Secondary / chemically induced, physiopathology* Reference Values Species Specificity Testosterone / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Drug Implants; 0/Levodopa; 0/Neurotoxins; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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