| Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. | |
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MedLine Citation:
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PMID: 19059388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resveratrol, a ubiquitous stress-induced phytoalexin, has demonstrated a wide variety of biological activities which make it a good candidate for the treatment of diabetes mellitus. The present study was aimed to evaluate its therapeutic potential by assaying the activities of key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. The daily oral treatment of resveratrol (5 mg/kg body weight) to diabetic rats for 30 days demonstrated a significant (p<0.05) decline in blood glucose and glycosylated hemoglobin levels and a significant (p<0.05) increase in plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver and kidney tissues of diabetic rats were significantly (p<0.05) reverted to near normal levels by the administration of resveratrol. Further, resveratrol administration to diabetic rats improved hepatic glycogen content suggesting the antihyperglycemic potential of resveratrol in diabetic rats. The obtained results were compared with glyclazide, a standard oral hypoglycemic drug. Thus, the modulatory effects of resveratrol on attenuating these enzymes activities afford a promise for widespread use for treatment of diabetes in the future. |
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Authors:
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P Palsamy; S Subramanian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-19 |
Journal Detail:
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Title: Chemico-biological interactions Volume: 179 ISSN: 1872-7786 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-03-24 Completed Date: 2009-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: Ireland |
Other Details:
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Languages: eng Pagination: 356-62 Citation Subset: IM |
Affiliation:
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Research Scholar, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamilnadu, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Carbohydrate Metabolism / drug effects* Diabetes Mellitus, Experimental / chemically induced, drug therapy*, enzymology*, metabolism Disease Models, Animal Drug Evaluation, Preclinical Fructose-Bisphosphatase / metabolism Gliclazide / pharmacology Glucose-6-Phosphatase / metabolism Glucosephosphate Dehydrogenase / metabolism Glycogen Phosphorylase / metabolism Glycogen Synthase / metabolism Hexokinase / metabolism Hypoglycemic Agents / chemistry, pharmacology* Kidney / enzymology L-Lactate Dehydrogenase / metabolism Liver / enzymology Male Niacinamide Pyruvate Kinase / metabolism Rats Rats, Wistar Stilbenes / chemistry, pharmacology* Streptozocin |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/Stilbenes; 18883-66-4/Streptozocin; 21187-98-4/Gliclazide; 501-36-0/resveratrol; 98-92-0/Niacinamide; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.4.1.-/Glycogen Phosphorylase; EC 2.4.1.11/Glycogen Synthase; EC 2.7.1.1/Hexokinase; EC 2.7.1.40/Pyruvate Kinase; EC 3.1.3.11/Fructose-Bisphosphatase; EC 3.1.3.9/Glucose-6-Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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