Document Detail

Modulatory effect of a complex fraction derived from colostrum on fibroblast contractibility and consequences on repair tissue.
MedLine Citation:
PMID:  21401885     Owner:  NLM     Status:  Publisher    
A complex compound (immune ('IM') fraction) from colostrum-derived whey was investigated for its potential wound healing properties. One of its most intriguing in vitro abilities was to significantly inhibit the contraction of collagen gel while fibroblast density remained as in control gels. This antagonist effect was dose dependent and fibroblasts in these gels did not exhibit any stress fibres. Subsequently, in vivo studies have been conducted in two wound models in guinea pigs. Daily application on full-thickness wounds of a liquid formulation of the IM fraction (first model) significantly delayed wound closure by contraction compared to what normally occurred in control wounds. In another wound model, a gel formulation of the IM fraction was applied on scar tissues, which resulted in a minimised residual scar on 5/8 wounds compared to corresponding wound areas seen prior to treatment. Conversely, most control wounds exhibited scar tissue from which 3/8 resembled hypertrophic scar tissue. Wound tissue treated with IM fraction covered a significantly larger area than in the control wounds, whereas the collagen deposition was unchanged as in the presence of α-smooth muscle actin. Thus, IM fraction may act by modulating the contraction rate and wound remodelling.
Charles J Doillon; Frédéric Lehance; Louis-Jean Bordeleau; Marie-Pier Laplante-Campbell; Réjean Drouin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  International wound journal     Volume:  -     ISSN:  1742-481X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. © 2011 Blackwell Publishing Ltd and Inc.
CJ Doillon, MD, PhD, Oncology and Molecular Endocrinology Research Center, CHUL Research Center, CHUQ, Quebec City, Quebec, Canada, Department of Surgery, Laval University, Quebec City, Quebec, Canada F Lehance, BSc, Advitech Inc., Quebec City, Quebec, Canada L-J Bordeleau, PhD, Oncology and Molecular Endocrinology Research Center, CHUL Research Center, CHUQ, Quebec City, Quebec, Canada M-P Laplante-Campbell, MSc, Advitech Inc., Quebec City, Quebec, Canada R Drouin, PhD, Advitech Inc., Quebec City, Quebec, Canada.
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