| Modulation of vascular tone and glycerol levels measured by in situ microdialysis in rat adipose tissue. | |
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MedLine Citation:
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PMID: 8897849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in blood flow induced by the beta-adrenoceptor agonist isoproterenol (Iso) and a stable analogue of the major metabolite of arachidonic acid in adipose tissue, carbaprostacyclin (cPGI2), have been studied in rat periepididymal fat pad with in situ microdialysis measuring the distribution ratio of 0.2% ethanol in the dialysate (outflow) to that in the perfusate (inflow) (O/I ratio). Local perfusions of 1 microM cPGI2 or 1 microM Iso led to reversible decreases of the O/I ratio that were similar to the decrease induced by the vasodilating reference drug hydralazine (Hydra, 630 microM). Interestingly, a continuous perfusion of Hydra at a submaximal vasodilating concentration (63 microM) was sufficient to prevent further vasodilatation induced by Iso or cPGI2. To take advantage of this observation, experiments were designed to evaluate the influence of the vasodilating effect of Iso or cPGI2 on the ability of either to induce lipolysis in vivo. The results showed that the vasodilating effect of Iso could contribute to glycerol removal from the extracellular fluid and demonstrate that cPGI2 was devoid of lipolytic activity. |
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Authors:
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C Darimont; P Saint-Marc; G Ailhaud; R Négrel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 271 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-12-16 Completed Date: 1996-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E631-5 Citation Subset: IM |
Affiliation:
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Centre de Biochimie, UMR 134, Centre National de la Recherche Scientifique, Université de Nice-Sophia Antipolis, Faculté des Sciences, Parc Valrose, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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blood supply*,
metabolism* Animals Epididymis Epoprostenol / analogs & derivatives*, pharmacology Glycerol / metabolism* Hydralazine / pharmacology Isoproterenol / pharmacology Lipolysis / drug effects Male Microdialysis Rats Rats, Wistar Regional Blood Flow Vasodilation / drug effects Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 35121-78-9/Epoprostenol; 56-81-5/Glycerol; 7683-59-2/Isoproterenol; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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