| Modulation of vascular tone control under isometric muscular stress: Role of estrogen receptors. | |
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MedLine Citation:
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PMID: 23070057 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: to evaluate isometric muscle contraction (handgrip) changes on key elements of cardiac afterload, before and after raloxifene administration in postmenopausal women. METHODS/RESULTS: 12 postmenopausal and 12 fertile women were studied. Postmenopausal women underwent raloxifene administration (60mg/day for 30days). We evaluated vascular reactivity in superficial palmar arterial arch during handgrip in postmenopausal women before and after (M+R) drug administration, and in controls. Blood flow was higher after raloxifene administration (p<0.05). Mean arterial pressure (MAP)/mean arterial flow (Fmed) and arterial pulse pressure (APP)/systolic maximum arterial flow (Fmax syst) were lower after raloxifene administration (p<0.001). Systolic blood pressure (SBP)/R-R ratio was higher in postmenopausal women than controls and M+R (p<0.01). End-handgrip systolic and diastolic blood pressure were higher in patients before raloxifene administration than in controls (p<0.001); diastolic and mean arterial pressure reduced after raloxifene administration (p<0.001). End-effort APP/Fmax syst-ratio before treatment were higher than baseline (p<0.05). Controls and no-treated patients showed a MAP/Fmed ratio at end-handgrip higher than M+R group and rest (p<0.05). Handgrip reduced R-R interval and increased SBP/R-R ratio in all groups (p<0.05). CONCLUSIONS: Raloxifene reduced the vascular effects of isometric muscle contraction by modulating the vasomotor tone of peripheral vessels in relation to exercise. |
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Authors:
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Marco Matteo Ciccone; Pietro Scicchitano; Francesca Cortese; Michele Gesualdo; Annapaola Zito; Maria Tesorio; Piero Guida; Annamaria Papagni; Antonio Federici; Ettore Cicinelli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
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Title: Vascular pharmacology Volume: - ISSN: 1879-3649 ISO Abbreviation: Vascul. Pharmacol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130615 Medline TA: Vascul Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy. Electronic address: ciccone@cardio.uniba.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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