Document Detail

Modulation of vascular reactivity to serotonin in the dog lung.
MedLine Citation:
PMID:  1917745     Owner:  NLM     Status:  MEDLINE    
Experiments were conducted to compare the effects of cyclooxygenase inhibition (COI) on vascular reactivity to serotonin (5-HT) in the isolated blood-perfused canine left lower lung lobe (LLL) and in isolated canine intrapulmonary lobar artery rings with and without a functional endothelium. LLLs (n = 6), perfused at constant blood flow, were challenged with bolus doses of 50, 100, and 250 micrograms 5-HT before COI, after COI with 45 microM meclofenamate, and after infusion of prostacyclin (PGI2) during COI. Lobar vascular resistance was segmentally partitioned by venous occlusion. Pulmonary arterial pressure increased from 13.5 +/- 1.0 to 16.3 +/- 0.8 cmH2O (P less than 0.01) after COI but declined to 13.1 +/- 1.1 cmH2O (P less than 0.01) subsequent to PGI2 infusion (91.3 +/- 14.5 ng.min-1.g LLL-1). The pulmonary arterial pressure changes were related to changes in postcapillary resistance. The dose-dependent pressor response to 5-HT was potentiated by COI (P less than 0.01) but reversibly attenuated (P less than 0.05) by PGI2 infusion. Isolated intrapulmonary artery rings (2-4 mm diam) exhibited a dose-related increase in contractile tension to 5-HT. The response to 5-HT was enhanced (P less than 0.05) in rings devoid of a functional endothelium. However, COI (10 microM indomethacin) did not alter (P greater than 0.05) the dose-related increase in contractile tension to 5-HT in rings with an intact endothelium. Our results suggest that both PGI2 and endothelium-derived relaxing factors modulate pulmonary vascular reactivity to 5-HT.(ABSTRACT TRUNCATED AT 250 WORDS)
W F Hofman; W F Jackson; H el-Kashef; I C Ehrhart
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  71     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-13     Completed Date:  1991-11-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912.
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MeSH Terms
Cyclooxygenase Inhibitors / pharmacology
Endothelium, Vascular / physiology
Epoprostenol / pharmacology
Methacholine Compounds / pharmacology
Muscle Contraction / drug effects,  physiology
Muscle Relaxation / drug effects,  physiology
Muscle Tonus / drug effects
Muscle, Smooth, Vascular / drug effects*
Pulmonary Artery / drug effects,  physiology
Pulmonary Circulation / drug effects*
Serotonin / pharmacology*
Vascular Resistance / drug effects
Grant Support
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Methacholine Compounds; 35121-78-9/Epoprostenol; 50-67-9/Serotonin

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