| Modulation of vagal actions on heart rate produced by inhibition of nitric oxide synthase in the anaesthetized ferret. | |
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MedLine Citation:
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PMID: 8737087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined a possible role for nitric oxide in the efferent vagal control of heart rate of the anaesthetized ferret, using stimulation of the motor fibres of the right vagus at supramaximal intensities and increasing frequencies. Propranolol was used to block beta-adrenergic actions on the heart. L-NAME (50-100 mg i.v.) significantly reduced the bradycardia induced by vagal stimulation at all frequencies tested (1-15 Hz); subsequent infusion of L-arginine (100-200 mg i.v.) restored the vagally induced heart rate responses to control levels. These results strongly suggest a role for nitric oxide in modulating the vagally mediated control of heart rate. |
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Authors:
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K Conlon; T Collins; C Kidd |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental physiology Volume: 81 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-11-12 Completed Date: 1996-11-12 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 547-50 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, Marischal College, Aberdeen, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / pharmacology Blood Pressure / drug effects, physiology Bradycardia / drug therapy Enzyme Inhibitors / pharmacology Ferrets Heart Rate / drug effects, physiology* NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / physiology* Nitric Oxide Synthase / antagonists & inhibitors* Propranolol / pharmacology Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 525-66-6/Propranolol; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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