Document Detail

Modulation of vagal actions on heart rate produced by inhibition of nitric oxide synthase in the anaesthetized ferret.
MedLine Citation:
PMID:  8737087     Owner:  NLM     Status:  MEDLINE    
We have examined a possible role for nitric oxide in the efferent vagal control of heart rate of the anaesthetized ferret, using stimulation of the motor fibres of the right vagus at supramaximal intensities and increasing frequencies. Propranolol was used to block beta-adrenergic actions on the heart. L-NAME (50-100 mg i.v.) significantly reduced the bradycardia induced by vagal stimulation at all frequencies tested (1-15 Hz); subsequent infusion of L-arginine (100-200 mg i.v.) restored the vagally induced heart rate responses to control levels. These results strongly suggest a role for nitric oxide in modulating the vagally mediated control of heart rate.
K Conlon; T Collins; C Kidd
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental physiology     Volume:  81     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-12     Completed Date:  1996-11-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  547-50     Citation Subset:  IM    
Department of Biomedical Sciences, Marischal College, Aberdeen, UK.
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MeSH Terms
Arginine / pharmacology
Blood Pressure / drug effects,  physiology
Bradycardia / drug therapy
Enzyme Inhibitors / pharmacology
Heart Rate / drug effects,  physiology*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / physiology*
Nitric Oxide Synthase / antagonists & inhibitors*
Propranolol / pharmacology
Vagus Nerve / physiology*
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 525-66-6/Propranolol; 74-79-3/Arginine; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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