| Modulation of urokinase-type plasminogen activator messenger RNA levels in human synovial fibroblasts by interleukin-1, retinoic acid, and a glucocorticoid. | |
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MedLine Citation:
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PMID: 3136776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have shown that mononuclear cell-conditioned medium (MCCM), interleukin-1 (IL-1), and all-trans-retinoic acid rapidly stimulate, while glucocorticoids lower, the urokinase-type plasminogen activator (u-PA) activity of human synovial fibroblast-like cells. It is now reported that MCCM, recombinant human IL-1 alpha (rHuIL-1 alpha), rHuIL-1 beta, and all-trans-retinoic acid elevate the u-PA messenger RNA (mRNA) levels to a steady-state value within 2 hours, while dexamethasone (10(-7)M) inhibits this increase. For both situations, when the u-PA activity is either stimulated or reduced, the changes in the u-PA mRNA levels parallel the changes in the u-PA activity, and it is suggested that modulation of gene transcription plays an important role. |
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Authors:
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G Vitti; J A Hamilton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 31 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-13 Completed Date: 1988-09-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1046-51 Citation Subset: AIM; IM |
Affiliation:
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University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Culture Media Dexamethasone / pharmacology* Enzyme Precursors / genetics* Fibroblasts / drug effects Humans Interleukin-1 / pharmacology* Plasminogen Activators / genetics* RNA, Messenger / drug effects* Recombinant Proteins / pharmacology Synovial Membrane / cytology* Time Factors Transcription, Genetic / drug effects Tretinoin / pharmacology* Urokinase-Type Plasminogen Activator / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Enzyme Precursors; 0/Interleukin-1; 0/RNA, Messenger; 0/Recombinant Proteins; 302-79-4/Tretinoin; 50-02-2/Dexamethasone; EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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