Document Detail


Modulation of upper airway muscle activities by bronchopulmonary afferents.
MedLine Citation:
PMID:  16675615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here we review the influence of bronchopulmonary receptors (slowly and rapidly adapting pulmonary stretch receptors, and pulmonary/bronchial C-fiber receptors) on respiratory-related motor output to upper airway muscles acting on the larynx, tongue, and hyoid arch. Review of the literature shows that all muscles in all three regions are profoundly inhibited by lung inflation, which excites slowly adapting pulmonary stretch receptors. This widespread coactivation includes the recruitment of muscles that have opposing mechanical actions, suggesting that the stiffness of upper airway muscles is highly regulated. A profound lack of information on the modulation of upper airway muscles by rapidly adapting receptors and bronchopulmonary C-fiber receptors prohibits formulation of a conclusive opinion as to their actions and underscores an urgent need for new studies in this area. The preponderance of the data support the view that discharge arising in slowly adapting pulmonary stretch receptors plays an important role in the initiation of the widespread and highly coordinated recruitment of laryngeal, tongue, and hyoid muscles during airway obstruction.
Authors:
E Fiona Bailey; Ralph F Fregosi
Related Documents :
3297055 - A disbalance between beta-adrenergic and muscarinic responses caused by hydrogen peroxi...
8013615 - Contractility of lungs and air-tubes: experiments performed in 1840 by charles j.b. wil...
9876775 - Beta-hexosaminidases: potent mitogens of airway smooth muscle.
2446545 - Neuropeptides in human airways: function and clinical implications.
8046725 - The soul and the pneuma in the function of the nervous system after galen.
24268475 - Feasibility and repeatability of cold and mechanical quantitative sensory testing in no...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2006-05-04
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  101     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-09-12     Revised Date:  2014-03-10    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  609-17     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Airway Obstruction / physiopathology
Animals
Bronchi / innervation,  physiology
Humans
Larynx / physiology
Lung / innervation,  physiology
Motor Neurons / physiology
Muscle, Skeletal / physiology
Nerve Fibers, Unmyelinated / physiology
Neurons, Afferent / physiology*
Pulmonary Stretch Receptors / physiology
Respiratory Muscles / innervation*,  physiology*
Tongue / physiology
Grant Support
ID/Acronym/Agency:
DC-07597/DC/NIDCD NIH HHS; HL-56876/HL/NHLBI NIH HHS; R01 DC007692/DC/NIDCD NIH HHS; R03 DC005728/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanisms for the control of respiratory evaporative heat loss in panting animals.
Next Document:  Thrombin-induced contraction in alveolar epithelial cells probed by traction microscopy.