| Modulation of systemic inflammatory response after cardiac surgery. | |
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MedLine Citation:
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PMID: 16304234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac surgery and cardiopulmonary bypass initiate a systemic inflammatory response largely determined by blood contact with foreign surfaces and the activation of complement. It is generally accepted that cardiopulmonary bypass initiates a whole-body inflammatory reaction. The magnitude of this inflammatory reaction varies, but the persistence of any degree of inflammation may be considered potentially harmful to the cardiac patient. The development of strategies to control the inflammatory response following cardiac surgery is currently the focus of considerable research efforts. Diverse techniques including maintenance of hemodynamic stability, minimization of exposure to cardiopulmonary bypass circuitry, and pharmacologic and immunomodulatory agents have been examined in clinical studies. This article briefly reviews the current concepts of the systemic inflammatory response following cardiac surgery, and the various therapeutic strategies being used to modulate this response. |
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Authors:
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Shahzad G Raja; Gilles D Dreyfus |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Asian cardiovascular & thoracic annals Volume: 13 ISSN: 0218-4923 ISO Abbreviation: Asian Cardiovasc Thorac Ann Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-23 Completed Date: 2006-04-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9503417 Medline TA: Asian Cardiovasc Thorac Ann Country: Singapore |
Other Details:
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Languages: eng Pagination: 382-95 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, Royal Hospital for Sick Children, Yorkhill NHS Trust, Dalnair Street, Glasgow G3 8SJ, Scotland, United Kingdom. drrajashahzad@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Surgical Procedures
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adverse effects*,
methods Cardiopulmonary Bypass / adverse effects*, methods Coated Materials, Biocompatible / therapeutic use Coronary Artery Bypass, Off-Pump / methods Endotoxemia / prevention & control Hemofiltration / methods Humans Surgical Procedures, Minimally Invasive / methods Systemic Inflammatory Response Syndrome / etiology*, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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