| Modulation of sulphobromophthalein excretion by ethacrynic acid. | |
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MedLine Citation:
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PMID: 1494888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Ethacrynic acid (EA), a phenoxyacetic acid diuretic, has similar effects to tienilic acid (TA) on rat liver glutathione S-transferase (GST) activity in vitro, using either 1-chloro-2,4-dinitrobenzene or sulphobromophthalein (BSP) as a substrate. EA inhibits the basic rat liver GST, with inhibition being greater with GST containing subunits 3 and 4 than with those containing subunits 1 and 2. 2. In vitro inhibitors of GST can inhibit biliary excretion of BSP in a perfused liver. 3. A single bolus dose of EA had no effect on BSP excretion from the isolated perfused rat liver, and this is most likely due to the rapid disappearance of EA from the perfusion media. Experiments using perfused rat liver indicated that a sustained high concentration of EA in the perfusion media has an inhibitory effect on the excretion of both unchanged and conjugated BSP. 4. A decrease in BSP excretion may not be an indicator of liver damage, but a consequence of GST inhibition. |
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Authors:
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S I James; J T Ahokas |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 22 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-03-08 Completed Date: 1993-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1433-9 Citation Subset: IM |
Affiliation:
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Key Centre for Applied and Nutritional Toxicology, RMIT University, Melbourne, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Ethacrynic Acid / pharmacokinetics, pharmacology* Glutathione Transferase / metabolism Liver / drug effects, metabolism Male Perfusion Rats Rats, Wistar Sulfobromophthalein / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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297-83-6/Sulfobromophthalein; 58-54-8/Ethacrynic Acid; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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