| Modulation of serotonergic and adrenergic systems by long-term antihypertensive treatment with enalapril. | |
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MedLine Citation:
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PMID: 1717198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enalapril (Renitec, Merck-Sharp-Dohne, Rahway, USA) administered alone (Group I), or in combination (Group II) in a dosage normalizing blood pressure (BP) was investigated for its ability to inhibit adrenergic and serotonergic systems in a one-year study. BP normalization was achieved. Serotonin (5-hydroxytryptamine, 5HT) levels in platelet rich and poor plasma, urinary excretion of 5HT, adrenaline and noradrenaline decreased. Correlations between the changes in BP and the inhibition of serotonergic and adrenergic systems were found in the acute phase in Group I. In chronic effect the reduction of BP correlated with inhibition of the serotonergic system in both groups. Changes in adrenergic and serotonergic systems correlated in the acute phase in both groups; during chronic treatment only in Group II. It is concluded that a concurrent antihypertensive effect and the inhibition of sympathetic activity and 5HT amplifying mechanism (antiatherogenic effect) are of clinical importance for hypertension treatment and prevention of its complications. |
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Authors:
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K Sebeková; K Jurecková; M Raucinová; I Balazovjech; R Dzúrik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cor et vasa Volume: 33 ISSN: 0010-8650 ISO Abbreviation: Cor Vasa Publication Date: 1991 |
Date Detail:
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Created Date: 1991-11-13 Completed Date: 1991-11-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372614 Medline TA: Cor Vasa Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 206-17 Citation Subset: IM |
Affiliation:
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Department of Pharmacotherapy, Comenius University Medical School, Bratislava, Czechoslovakia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects Catecholamines / metabolism* Enalapril / therapeutic use* Epinephrine / metabolism Humans Hydroxyindoleacetic Acid / metabolism Hypertension / drug therapy*, metabolism, physiopathology Male Middle Aged Norepinephrine / metabolism Serotonin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 54-16-0/Hydroxyindoleacetic Acid; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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