| Modulation of salivary secretion by acid infusion in the distal esophagus in humans. | |
| | |
MedLine Citation:
|
PMID: 1451977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To examine the relationship between esophageal acid exposure and development of salivation and heartburn, 15 healthy subjects underwent perfusion of the distal esophagus with varying concentrations of hydrochloric acid, different-osmolality saline solutions, and deionized water. In five study subjects, hydrochloric acid was infused in the body of the stomach only. During the study, timed samples of whole and parotid saliva were collected and analyzed for flow rate and bicarbonate concentration. Only hydrochloric acid concentrations of 20 mmol/L or greater (pH 1.8 or lower) induced a rapid (within 2 minutes) and significant (P < 0.05) increase in salivation. The hydrochloric acid-induced salivation was associated with significant (P < 0.05) increase in bicarbonate secretion in both parotid and whole saliva samples. Intravenous atropine administration completely inhibited hydrochloric acid-induced salivary secretion in all six subjects. Changes in osmolality of saline solution infused in the esophagus and hydrochloric acid infused in the stomach did not significantly alter parotid and whole saliva flow rates. These data suggest that in humans, rapid salivation in response to esophageal mucosal exposure to intraluminal hydrochloric acid is a pH-dependent and osmolality-independent phenomenon that is most likely mediated by pH-sensitive chemoreceptors located in the esophageal mucosa. |
| | |
Authors:
|
S K Dutta; H B Matossian; R F Meirowitz; J Vaeth |
Related Documents
:
|
12616337 - Interleukin 1 beta-induced inhibition of gastric acid secretion involves glutamate, no ... 1269847 - Secretin and insulin: response to intraduodenal acid. 3080277 - Effect of cck-op and intraduodenal administration of essential amino acids on intralumi... 9105407 - Evidence for the involvement of a muscarinic receptor in ascorbic acid secretion in the... 19115837 - Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from... 3141687 - Biochemical, clinical, genetic and metabolic studies of hyperapo-beta-lipoproteinaemia. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Gastroenterology Volume: 103 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1992 Dec |
Date Detail:
|
Created Date: 1993-01-07 Completed Date: 1993-01-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1833-41 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, VA Medical Center, Baltimore, Maryland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Bicarbonates / metabolism Esophagitis / etiology Esophagus / drug effects*, physiology Heartburn / etiology Humans Hydrochloric Acid / pharmacology* Hydrogen-Ion Concentration Male Middle Aged Salivation / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Bicarbonates; 7647-01-0/Hydrochloric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Estradiol is trophic for colon cancer in mice: effect on ornithine decarboxylase and c-myc messenger...
Next Document: Decreased expression of transforming growth factor alpha during differentiation of human pancreatic ...